The endoplasmic reticulum (ER) is an important organelle involved in protein quality control
and cellular homeostasis. The accumulation of unfolded proteins leads to an ER stress …

Prion diseases are progressive, incurable and fatal neurodegenerative conditions. The term
'prion'was first nominated to express the revolutionary concept that a protein could be …

In eukaryotic cells, the endoplasmic reticulum (ER) is the cell compartment involved in
secretory protein translocation and quality control of secretory protein folding. Different …

The endoplasmic reticulum (ER) is susceptible to wear-and-tear and proteotoxic stress,
necessitating its turnover. Here, we show that the N-degron pathway mediates ER-phagy …

Aberrant accumulation of misfolded proteins into amyloid deposits is a hallmark in many age-
related neurodegenerative diseases, including Alzheimer's disease (AD), Parkinson's …

Introduction Hemophilia comprises a group of X-linked hemorrhagic disorders that result
from a deficiency of coagulation factors. The disorder affects mainly males and leads to …

Pharmacological research has expanded to the nanoscale level with advanced imaging
technologies, enabling the analysis of drug distribution at the cellular organelle level. These …

As people age, their risks of develo** degenerative diseases such as cancer, diabetes,
Parkinson's Disease (PD), Alzheimer's Disease (AD), rheumatoid arthritis, and osteoporosis …

Higher prevalence of neurodegenerative diseases is strictly connected with progressive
aging of the world population. Interestingly, a broad range of age-related …

Coronavirus disease 2019 (COVID-19), the seventh human coronavirus infectious disease,
was first reported in Wuhan, China, in December 2019, followed by its rapid spread globally …