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mTOR at the nexus of nutrition, growth, ageing and disease
The mTOR pathway integrates a diverse set of environmental cues, such as growth factor
signals and nutritional status, to direct eukaryotic cell growth. Over the past two and a half …
signals and nutritional status, to direct eukaryotic cell growth. Over the past two and a half …
Clinical delivery of circular RNA: lessons learned from RNA drug development
Circular RNAs (circRNA) represent a distinct class of covalently closed-loop RNA molecules,
which play diverse roles in regulating biological processes and disease states. The …
which play diverse roles in regulating biological processes and disease states. The …
AMPK and TOR: the yin and yang of cellular nutrient sensing and growth control
The AMPK (AMP-activated protein kinase) and TOR (target-of-rapamycin) pathways are
interlinked, opposing signaling pathways involved in sensing availability of nutrients and …
interlinked, opposing signaling pathways involved in sensing availability of nutrients and …
[HTML][HTML] Increased demand for NAD+ relative to ATP drives aerobic glycolysis
Aerobic glycolysis, or preferential fermentation of glucose-derived pyruvate to lactate despite
available oxygen, is associated with proliferation across many organisms and conditions. To …
available oxygen, is associated with proliferation across many organisms and conditions. To …
SCENITH: a flow cytometry-based method to functionally profile energy metabolism with single-cell resolution
Energetic metabolism reprogramming is critical for cancer and immune responses. Current
methods to functionally profile the global metabolic capacities and dependencies of cells are …
methods to functionally profile the global metabolic capacities and dependencies of cells are …
[HTML][HTML] Trem2 expression in microglia is required to maintain normal neuronal bioenergetics during development
Triggering receptor expressed on myeloid cells 2 (Trem2) is a myeloid cell-specific gene
expressed in brain microglia, with variants that are associated with neurodegenerative …
expressed in brain microglia, with variants that are associated with neurodegenerative …
[HTML][HTML] Neurons release serine to support mRNA translation in pancreatic cancer
Pancreatic ductal adenocarcinoma (PDAC) tumors have a nutrient-poor, desmoplastic, and
highly innervated tumor microenvironment. Although neurons can release stimulatory factors …
highly innervated tumor microenvironment. Although neurons can release stimulatory factors …
The maintenance of oocytes in the mammalian ovary involves extreme protein longevity
Women are born with all of their oocytes. The oocyte proteome must be maintained with
minimal damage throughout the woman's reproductive life, and hence for decades. Here we …
minimal damage throughout the woman's reproductive life, and hence for decades. Here we …
Quantifying intracellular rates of glycolytic and oxidative ATP production and consumption using extracellular flux measurements
Partitioning of ATP generation between glycolysis and oxidative phosphorylation is central
to cellular bioenergetics but cumbersome to measure. We describe here how rates of ATP …
to cellular bioenergetics but cumbersome to measure. We describe here how rates of ATP …
The mTOR–autophagy axis and the control of metabolism
N Deleyto-Seldas, A Efeyan - Frontiers in cell and developmental …, 2021 - frontiersin.org
The mechanistic target of rapamycin (mTOR), master regulator of cellular metabolism, exists
in two distinct complexes: mTOR complex 1 and mTOR complex 2 (mTORC1 and 2) …
in two distinct complexes: mTOR complex 1 and mTOR complex 2 (mTORC1 and 2) …