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Molecular mechanisms of resistance and treatment efficacy of clofazimine and bedaquiline against Mycobacterium tuberculosis
Clofazimine (CFZ) and bedaquiline (BDQ) are currently used for the treatment of multidrug-
resistant (MDR) Mycobacterium tuberculosis (Mtb) strains. In recent years, adding CFZ and …
resistant (MDR) Mycobacterium tuberculosis (Mtb) strains. In recent years, adding CFZ and …
Emergence of bedaquiline-resistant tuberculosis and of multidrug-resistant and extensively drug-resistant Mycobacterium tuberculosis strains with rpoB Ile491Phe …
I Barilar, T Fernando, C Utpatel, C Abujate… - The Lancet Infectious …, 2024 - thelancet.com
Background In 2021, an estimated 4800 people developed rifampicin-resistant tuberculosis
in Mozambique, 75% of which went undiagnosed. Detailed molecular data on rifampicin …
in Mozambique, 75% of which went undiagnosed. Detailed molecular data on rifampicin …
Commensal antimicrobial resistance mediates microbiome resilience to antibiotic disruption
Despite their therapeutic benefits, antibiotics exert collateral damage on the microbiome and
promote antimicrobial resistance. However, the mechanisms governing microbiome …
promote antimicrobial resistance. However, the mechanisms governing microbiome …
Quantitative measurement of antibiotic resistance in Mycobacterium tuberculosis reveals genetic determinants of resistance and susceptibility in a target gene …
Nature communications, 2024 - nature.com
Abstract The World Health Organization has a goal of universal drug susceptibility testing for
patients with tuberculosis. However, molecular diagnostics to date have focused largely on …
patients with tuberculosis. However, molecular diagnostics to date have focused largely on …
[HTML][HTML] Genomic Characterization of Drug-Resistant Mycobacterium tuberculosis L2/Bei**g Isolates from Astana, Kazakhstan
D Auganova, S Atavliyeva, A Amirgazin, A Akisheva… - Antibiotics, 2023 - mdpi.com
Kazakhstan ranks among the countries with the highest number of MDR-TB patients per
100,000 population worldwide. The successful transmission of local MDR strains of …
100,000 population worldwide. The successful transmission of local MDR strains of …
A Narrative Review of Bedaquiline and Delamanid: New Arsenals Against Multidrug‐Resistant and Extensively Drug‐Resistant Mycobacterium tuberculosis
N Ahmad Khosravi, M Sirous… - Journal of Clinical …, 2024 - Wiley Online Library
Background The treatment of multidrug‐resistant (MDR‐) and extensively drug‐resistant
tuberculosis (XDR‐TB) is a formidable challenge. Treatment of MDR‐and XDR‐TB using …
tuberculosis (XDR‐TB) is a formidable challenge. Treatment of MDR‐and XDR‐TB using …
Genotype–Phenotype Characterization of Serial Mycobacterium tuberculosis Isolates in Bedaquiline-Resistant Tuberculosis
TS Brown, L Tang, SV Omar, L Joseph… - Clinical Infectious …, 2024 - academic.oup.com
Background Emerging resistance to bedaquiline (BDQ) threatens to undermine advances in
the treatment of drug-resistant tuberculosis (DRTB). Characterizing serial Mycobacterium …
the treatment of drug-resistant tuberculosis (DRTB). Characterizing serial Mycobacterium …
Leveraging large-scale Mycobacterium tuberculosis whole genome sequence data to characterise drug-resistant mutations using machine learning and statistical …
Tuberculosis disease (TB), caused by Mycobacterium tuberculosis (Mtb), is a major global
public health problem, resulting in> 1 million deaths each year. Drug resistance (DR) …
public health problem, resulting in> 1 million deaths each year. Drug resistance (DR) …
Prison as a driver of recent transmissions of multidrug-resistant tuberculosis in Callao, Peru: a cross-sectional study
C Utpatel, M Zavaleta, D Rojas-Bolivar… - The Lancet Regional …, 2024 - thelancet.com
Background We sought to identify resistance patterns and key drivers of recent multidrug-
resistant tuberculosis (MDR-TB) transmission in a TB-prevalent area in Peru. Methods Cross …
resistant tuberculosis (MDR-TB) transmission in a TB-prevalent area in Peru. Methods Cross …
First detection of a Mycobacterium tuberculosis XDR clinical isolate harbouring an RpoB I491F mutation in a Ukrainian patient treated in Germany, October 2023
I Friesen, V Dreyer, A Klingmüller, S Zuber… - …, 2024 - pmc.ncbi.nlm.nih.gov
This report documents the case of a Ukrainian patient infected with an extensively drug-
resistant (XDR) lineage 2 Mycobacterium tuberculosis strain harbouring the rifampicin …
resistant (XDR) lineage 2 Mycobacterium tuberculosis strain harbouring the rifampicin …