Tumor suppressor genes
RA Weinberg - Science, 1991 - science.org
For the past decade, cellular oncogenes have attracted the attention of biologists intent on
understanding the molecular origins of cancer. As the present decade unfolds, oncogenes …
understanding the molecular origins of cancer. As the present decade unfolds, oncogenes …
Egr transcription factors in the nervous system
AM Beckmann, PA Wilce - Neurochemistry international, 1997 - Elsevier
The Egr proteins, Egr-1, Egr-2, Egr-3 and Egr-4, are closely related members of a subclass
of immediate early gene-encoded, inducible transcription factors. They share a highly …
of immediate early gene-encoded, inducible transcription factors. They share a highly …
BAP1: a novel ubiquitin hydrolase which binds to the BRCA1 RING finger and enhances BRCA1-mediated cell growth suppression
DE Jensen, M Proctor, ST Marquis, HP Gardner, SI Ha… - Oncogene, 1998 - nature.com
We have identified a novel protein, BAP1, which binds to the RING finger domain of the
Breast/Ovarian Cancer Susceptibility Gene product, BRCA1. BAP1 is a nuclear-localized …
Breast/Ovarian Cancer Susceptibility Gene product, BRCA1. BAP1 is a nuclear-localized …
KAP-1, a novel corepressor for the highly conserved KRAB repression domain.
JR Friedman, WJ Fredericks, DE Jensen… - Genes & …, 1996 - genesdev.cshlp.org
The KRAB repression domain is one of the most widely distributed transcriptional effector
domains yet identified, but its mechanism of repression is unknown. We have cloned a …
domains yet identified, but its mechanism of repression is unknown. We have cloned a …
Krüppel-associated boxes are potent transcriptional repression domains.
JF Margolin, JR Friedman, WK Meyer… - Proceedings of the …, 1994 - National Acad Sciences
The Krüppel-associated box (KRAB) is a highly conserved, 75-aa region containing two
predicted amphipathic alpha-helices. The KRAB domain is present in the amino-terminal …
predicted amphipathic alpha-helices. The KRAB domain is present in the amino-terminal …
WT1 as a new prognostic factor and a new marker for the detection of minimal residual disease in acute leukemia
K Inoue, H Sugiyama, H Ogawa, M Nakagawa… - 1994 - ashpublications.org
The WT1 gene encoding a zinc finger polypeptide is a tumor suppressor gene that plays a
key role in the carcinogenesis of Wilms' tumor. Reverse transcriptase-polymerase chain …
key role in the carcinogenesis of Wilms' tumor. Reverse transcriptase-polymerase chain …
The expression of the Wilms' tumour gene, WT1, in the develo** mammalian embryo
In the develo** mouse, the Wilms' tumour gene, WT1, is first expressed in the intermediate
mesenchyme lateral to the coelomic cavity (13 somite, early 9 dpc embryo). A few hours …
mesenchyme lateral to the coelomic cavity (13 somite, early 9 dpc embryo). A few hours …
Mad-Max transcriptional repression is mediated by ternary complex formation with mammalian homologs of yeast repressor Sin3
Summary The bHLH-ZIP protein Mad heterodimerizes with Max as a sequence-specific
transcriptional repressor. Mad is rapidly induced upon differentiation, and the associated …
transcriptional repressor. Mad is rapidly induced upon differentiation, and the associated …
WT1 proteins: functions in growth and differentiation
V Scharnhorst, AJ van der Eb, AG Jochemsen - Gene, 2001 - Elsevier
The Wilms' tumor 1 gene (WT1) has been identified as a tumor suppressor gene involved in
the etiology of Wilms' tumor. Approximately 10% of all Wilms' tumors carry mutations in the …
the etiology of Wilms' tumor. Approximately 10% of all Wilms' tumors carry mutations in the …
Promiscuous partnerships in Ewing's sarcoma
S Sankar, SL Lessnick - Cancer genetics, 2011 - Elsevier
Ewing's sarcoma is a highly aggressive bone and soft tissue tumor of children and young
adults. At the molecular genetic level Ewing's sarcoma is characterized by a balanced …
adults. At the molecular genetic level Ewing's sarcoma is characterized by a balanced …