Tendon aging is associated with an increasing prevalence of tendon injuries and/or chronic
tendon diseases, such as tendinopathy, which affects approximately 25% of the adult …

Tendon is a bradytrophic and hypovascular tissue, hence, healing remains a major
challenge. The molecular key events involved in successful repair have to be unravelled to …

Limb development has long served as a model system for coordinated spatial patterning of
progenitor cells. Here, we identify a population of naive limb progenitors and show that they …

Tenomodulin (Tnmd) is the best-known mature marker for tendon and ligament lineage
cells. It is important for tendon maturation, running performance and has key implications for …

Tendinopathy, the most common disorder affecting tendons, is characterized by chronic
disorganization of the tendon matrix, which leads to tendon tear and rupture. The goal was …

Aging is a complex and progressive process where the tissues of the body demonstrate a
decreased ability to maintain homeostasis. During aging, there are substantial cellular and …

Abstract In his Lissner Award medal lecture in 2000, Stephen Cowin asked the
question:“How is a tissue built?” It is not a new question, but it remains as relevant today as it …

Tendons and tendon interfaces have a very limited regenerative capacity, rendering their
injuries clinically challenging to resolve. Tendons sense muscle-mediated load; however …

Both tendon injuries and tendinopathies, particularly rotator cuff tears, increase with tendon
aging. Tendon stem cells play important roles in promoting tendon growth, maintenance …

Derangements in tendon matrisome are pathognomonic for musculoskeletal disorders
including rotator cuff tendinopathies (RCT). Collagen type-1 accounts for more than 85% of …