[HTML][HTML] Obesity as a risk factor for dementia and Alzheimer's disease: the role of leptin

JA Flores-Cordero, A Pérez-Pérez… - International journal of …, 2022 - mdpi.com
Obesity is a growing worldwide health problem, affecting many people due to excessive
saturated fat consumption, lack of exercise, or a sedentary lifestyle. Leptin is an adipokine …

Structural brain changes associated with overweight and obesity

E Gómez-Apo, A Mondragón-Maya… - Journal of …, 2021 - Wiley Online Library
Obesity is a global health problem with a broad set of comorbidities, such as malnutrition,
metabolic syndrome, diabetes, systemic hypertension, heart failure, and kidney failure. This …

Cognitive aging and the promise of physical activity

KI Erickson, SD Donofry, KR Sewell… - Annual Review of …, 2022 - annualreviews.org
Is the field of cognitive aging irretrievably concerned with decline and deficits, or is it shifting
to emphasize the hope of preservation and enhancement of cognitive function in late life? A …

Executive function performance in obesity and overweight individuals: A meta-analysis and review

Y Yang, GS Shields, C Guo, Y Liu - Neuroscience & Biobehavioral …, 2018 - Elsevier
Prior research has suggested that obesity/overweight may be associated with deficits in
executive function. If true, this has important clinical implications. In this review, we …

Obesity and neuroinflammation: a pathway to cognitive impairment

AA Miller, SJ Spencer - Brain, behavior, and immunity, 2014 - Elsevier
Obesity is a growing problem worldwide and is associated with a range of comorbidities,
including cognitive dysfunction. In this review we will address the evidence that obesity and …

The role of leptin and adiponectin in obesity-associated cognitive decline and Alzheimer's disease

L Forny-Germano, FG De Felice… - Frontiers in …, 2019 - frontiersin.org
Cross-talk between adipose tissue and central nervous system (CNS) underlies the
increased risk of obese people to develop brain diseases such as cognitive and mood …

Enhancing intestinal barrier efficiency: A novel metabolic diseases therapy

Y Zhang, X Zhu, X Yu, P Novák, Q Gui, K Yin - Frontiers in nutrition, 2023 - frontiersin.org
Physiologically, the intestinal barrier plays a crucial role in homeostasis and nutrient
absorption and prevents pathogenic entry, harmful metabolites, and endotoxin absorption …

Inhibitory control in obesity and binge eating disorder: A systematic review and meta-analysis of neurocognitive and neuroimaging studies

L Lavagnino, D Arnone, B Cao, JC Soares… - … & Biobehavioral Reviews, 2016 - Elsevier
The ability to exercise appropriate inhibitory control is critical in the regulation of body
weight, but the exact mechanisms are not known. In this systematic review, we identified 37 …

Obesity, brain volume, and white matter microstructure at MRI: a cross-sectional UK biobank study

IA Dekkers, PR Jansen, HJ Lamb - Radiology, 2019 - pubs.rsna.org
Background Obesity has been associated with increased risk of accelerated cognitive
decline and dementia, which suggests underlying neurobiological changes. Purpose To …

Association of body mass index and waist-to-hip ratio with brain structure: UK Biobank study

M Hamer, GD Batty - Neurology, 2019 - neurology.org
Objective To examine the association of body mass index (BMI) and waist-to-hip ratio (WHR)
with brain volume. Methods We used cross-sectional data from the UK Biobank study (n …