Recent development of multifunctional agents as potential drug candidates for the treatment of Alzheimer's disease
N Guzior, A Wieckowska, D Panek… - Current medicinal …, 2015 - ingentaconnect.com
Alzheimer's disease (AD) is a complex and progressive neurodegenerative disorder. The
available therapy is limited to the symptomatic treatment and its efficacy remains …
available therapy is limited to the symptomatic treatment and its efficacy remains …
[HTML][HTML] A review of butyrylcholinesterase as a therapeutic target in the treatment of Alzheimer's disease
A Nordberg, C Ballard, R Bullock… - The primary care …, 2013 - legacy.psychiatrist.com
Objective: To examine the role of butyrylcholinesterase (BuChE) in cholinergic signaling and
neurologic conditions, such as Alzheimer's disease (AD). The rationale for inhibiting …
neurologic conditions, such as Alzheimer's disease (AD). The rationale for inhibiting …
Target enzyme in Alzheimer's disease: Acetylcholinesterase inhibitors
M Saxena, R Dubey - Current topics in medicinal chemistry, 2019 - ingentaconnect.com
Alzheimer's Disease (AD), affecting a large population worldwide is characterized by the
loss of memory and learning ability in the old population. The enzyme Acetylcholinesterase …
loss of memory and learning ability in the old population. The enzyme Acetylcholinesterase …
Protein misfolding and aggregation in Alzheimer's disease and type 2 diabetes mellitus
In general, proteins can only execute their various biological functions when they are
appropriately folded. Their amino acid sequence encodes the relevant information required …
appropriately folded. Their amino acid sequence encodes the relevant information required …
Structure and therapeutic uses of butyrylcholinesterase: application in detoxification, Alzheimer's disease, and fat metabolism
S **ng, Q Li, B **ong, Y Chen, F Feng… - Medicinal Research …, 2021 - Wiley Online Library
Structural information of butyrylcholinesterase (BChE) and its variants associated with
several diseases are discussed here. Pure human BChE has been proved safe and effective …
several diseases are discussed here. Pure human BChE has been proved safe and effective …
Recent research progress on natural small molecule bibenzyls and its derivatives in Dendrobium species
L He, Q Su, L Bai, M Li, J Liu, X Liu, C Zhang… - European Journal of …, 2020 - Elsevier
Orchidaceous plant Dendrobium genus is often used as a tonic, and its phenolic
components have attracted attention for its anti-tumor and anti-diabetic complications …
components have attracted attention for its anti-tumor and anti-diabetic complications …
Amyloid–cholinesterase interactions: implications for Alzheimer's disease
Acetylcholinesterase is an enzyme associated with senile plaques. Biochemical studies
have indicated that acetylcholinesterase induces amyloid fibril formation by interaction …
have indicated that acetylcholinesterase induces amyloid fibril formation by interaction …
Lipid rafts and Alzheimer's disease: protein-lipid interactions and perturbation of signaling
Lipid rafts are membrane domains, more ordered than the bulk membrane and enriched in
cholesterol and sphingolipids. They represent a platform for protein-lipid and protein–protein …
cholesterol and sphingolipids. They represent a platform for protein-lipid and protein–protein …
Tacrine derivatives and Alzheimer's disease
To date, the pharmacotherapy of Alzheimer's disease (AD) has relied on
acetylcholinesterase (AChE) inhibitors (AChEIs) and, more recently, an N-methyl-D …
acetylcholinesterase (AChE) inhibitors (AChEIs) and, more recently, an N-methyl-D …
Cholinesterases and the fine line between poison and remedy
Abstract Acetylcholinesterase (AChE, EC 3.1. 1.7) and butyrylcholinesterase (BChE, EC 3.1.
1.8) are related enzymes found across the animal kingdom. The critical role of …
1.8) are related enzymes found across the animal kingdom. The critical role of …