Listeria monocytogenes is a Gram-positive facultative intracellular pathogen that can cause
severe invasive infections upon ingestion with contaminated food. Clinically, listerial …

Bacterial pathogens exploit a huge range of niches within their hosts. Many pathogens can
invade non-phagocytic cells and survive within a membrane-bound compartment. However …

Listeria monocytogenes is an intracellular Gram-positive pathogen and the etiological agent
of listeriosis, a human food-borne disease potentially fatal for certain risk groups. The …

Although the structure of lipoic acid and its role in bacterial metabolism were clear over 50
years ago, it is only in the past decade that the pathways of biosynthesis of this universally …

The ability of the human body to play host to bacterial pathogens has been studied for more
than 200 years. Successful pathogenesis relies on the ability to acquire the nutrients that are …

ABSTRACT The Gram-positive pathogen Listeria monocytogenes is able to promote its entry
into a diverse range of mammalian host cells by triggering plasma membrane remodeling …

Why do organisms “eat”? This core question drives the study of biochemistry—specifically
metabolism. The short answer to this seemingly simple question is 2‐fold: first, eating …

SUMMARY Lipoic acid [(R)-5-(1, 2-dithiolan-3-yl) pentanoic acid] is an enzyme cofactor
required for intermediate metabolism in free-living cells. Lipoic acid was discovered nearly …

Listeria monocytogenes is a human intracellular pathogen able to colonize host tissues after
ingestion of contaminated food, causing severe invasive infections. In order to gain a better …

Intracellular bacterial pathogens are metabolically adapted to grow within mammalian cells.
While these adaptations are fundamental to the ability to cause disease, we know little about …