Water solubility and structural stability are key merits for proteins defined by the primary
sequence and 3D-conformation. Their manipulation represents important aspects of the …

Infectious diseases are the second most important cause of human death worldwide;
Staphylococcus aureus (S. aureus) is a very common human pathogenic microorganism that …

The aggregation of proteins into amyloid fibrils and their deposition into plaques and
intracellular inclusions is the hallmark of amyloid disease. The accumulation and deposition …

Circular dichroism (CD) spectroscopy is a widely used method to study the protein
secondary structure. However, for decades, the general opinion was that the correct …

Amyloid proteins, which are considered 'villains' in many neurodegenerative diseases, form
enigmatic pathological strains that underlie disease pathogenesis and progression. Recent …

The discovery of alternative signaling pathways that regulate cell death has revealed
multiple strategies for promoting cell death with diverse consequences at the tissue and …

Peptide self-assemblies show intriguing and tunable physicochemical properties, and thus
have been attracting increasing interest over the last two decades. However, the micro/nano …

Peptide-based supramolecular assemblies are a promising class of nanomaterials with
important biomedical applications, specifically in drug delivery and tissue regeneration …

Proteins are molecular machines whose function depends on their ability to achieve
complex folds with precisely defined structural and dynamic properties. The rational design …

The RIPK1-RIPK3 necrosome is an amyloid signaling complex that initiates TNF-induced
necroptosis, serving in human immune defense, cancer, and neurodegenerative diseases …