Abstract Background Male Infertility is a prevalent condition worldwide, and a substantial
fraction of cases are thought to have a genetic basis. Investigations into the responsible …

It is estimated that approximately 25% of nonobstructive azoospermia (NOA) cases are
caused by single genetic anomalies, including chromosomal aberrations and gene …

At the moment of union in fertilization, sperm and oocyte are transcriptionally silent. The
ensuing onset of embryonic transcription (embryonic genome activation [EGA]) is critical for …

The female reproductive lifespan is highly dependent on egg quality, especially the
presence of a normal number of chromosomes in an egg, known as euploidy. Mistakes in …

Meiotic recombinases RAD51 and DMC1 mediate strand exchange in the repair of DNA
double-strand breaks (DSBs) by homologous recombination. This is a landmark event of …

Aneuploidy, the presence of a chromosomal anomaly, is a major cause of spontaneous
abortions and recurrent pregnancy loss in humans. However, the underlying molecular …

Abstract Ste20‐like kinase (SLK) is involved in cell proliferation and migration in somatic
cells. This study aims to explore SLK expression and function in mouse oocyte meiosis …

During meiosis, at least one crossover must occur per homologous chromosome pair to
ensure normal progression of meiotic division and accurate chromosome segregation …

Prime editing (PE), a recent progression in CRISPR-based technologies, holds promise for
precise genome editing without the risks associated with double-strand breaks. It can …

The recently characterised human ZGRF1 helicase promotes genomic stability by facilitating
DNA interstrand crosslink repair. In its absence, human cells exhibit greater sensitivity …