Carbapenem-Resistant Klebsiella pneumoniae: Virulence Factors, Molecular Epidemiology and Latest Updates in Treatment Options

T Karampatakis, K Tsergouli, P Behzadi - Antibiotics, 2023 - mdpi.com
Klebsiella pneumoniae is a Gram-negative opportunistic pathogen responsible for a variety
of community and hospital infections. Infections caused by carbapenem-resistant K …

Clinical epidemiology of the global expansion of Klebsiella pneumoniae carbapenemases

LS Munoz-Price, L Poirel, RA Bonomo… - The Lancet infectious …, 2013 - thelancet.com
Klebsiella pneumoniae carbapenemases (KPCs) were originally identified in the USA in
1996. Since then, these versatile β-lactamases have spread internationally among Gram …

Antibiotic resistance in Enterobacteriaceae: mechanisms and clinical implications

J Iredell, J Brown, K Tagg - Bmj, 2016 - bmj.com
Resistance of the Enterobacteriaceae to antibiotics, especially of the β lactam type, is
increasingly dominated by the mobilization of continuously expressed single genes that …

Deaths attributable to carbapenem-resistant Enterobacteriaceae infections

ME Falagas, GS Tansarli… - Emerging infectious …, 2014 - pmc.ncbi.nlm.nih.gov
We evaluated the number of deaths attributable to carbapenem-resistant
Enterobacteriaceae by using studies from around the world published before April 9, 2012 …

Predictors of Mortality in Bloodstream Infections Caused by Klebsiella pneumoniae Carbapenemase–Producing K. pneumoniae: Importance of Combination …

M Tumbarello, P Viale, C Viscoli… - Clinical infectious …, 2012 - academic.oup.com
Abstract Background. The spread of Klebsiella pneumoniae (Kp) strains that produce K.
pneumoniae carbapenemases (KPCs) has become a significant problem, and treatment of …

[HTML][HTML] Rapid evolution and spread of carbapenemases among Enterobacteriaceae in Europe

R Cantón, M Akóva, Y Carmeli, CG Giske… - Clinical microbiology …, 2012 - Elsevier
Plasmid-acquired carbapenemases in Enterobacteriaceae, which were first discovered in
Europe in the 1990s, are now increasingly being identified at an alarming rate. Although …

Multiresistant Gram-negative bacteria: the role of high-risk clones in the dissemination of antibiotic resistance

N Woodford, JF Turton… - FEMS microbiology …, 2011 - academic.oup.com
Multilocus sequence ty** reveals that many bacterial species have a clonal structure and
that some clones are widespread. This underlying phylogeny was not revealed by pulsed …

Alarming β-lactamase-mediated resistance in multidrug-resistant Enterobacteriaceae

K Bush - Current opinion in microbiology, 2010 - Elsevier
Resistance to β-lactams and other antibiotics in the Enterobacteriaceae is frequently
associated with plasmidic resistance determinants that are easily transferred among …

Detection and treatment options for Klebsiella pneumoniae carbapenemases (KPCs): an emerging cause of multidrug-resistant infection

EB Hirsch, VH Tam - Journal of Antimicrobial Chemotherapy, 2010 - academic.oup.com
Bacteria producing Klebsiella pneumoniae carbapenemases (KPCs) are rapidly emerging
as a cause of multidrug-resistant infections worldwide. Bacterial isolates harbouring these …

[HTML][HTML] Predictors of mortality in patients with bloodstream infections caused by KPC-producing Klebsiella pneumoniae and impact of appropriate antimicrobial …

O Zarkotou, S Pournaras, P Tselioti… - Clinical Microbiology …, 2011 - Elsevier
Bloodstream infections (BSIs) caused by Klebsiella pneumoniae carbapenemases (KPC)-
producing K. pneumoniae (KPC-KP) are associated with high mortality rates. We …