Lysozyme is a cornerstone of innate immunity. The canonical mechanism for bacterial killing
by lysozyme occurs through the hydrolysis of cell wall peptidoglycan (PG). Conventional …

Lysozymes are hydrolytic enzymes characterized by their ability to cleave the β-(1, 4)-
glycosidic bonds in peptidoglycan, a major structural component of the bacterial cell wall …

Gram-positive organisms, including the pathogens Staphylococcus aureus, Streptococcus
pneumoniae, and Enterococcus faecalis, have dynamic cell envelopes that mediate …

Over the past few decades, we have witnessed a surge around the world in the emergence
of antibiotic-resistant bacteria. This global health threat arose mainly due to the overuse and …

Peptidoglycan (PG) is the major structural component of the bacterial cell wall. Bacteria have
autolytic PG hydrolases that allow the cell to grow and divide. A well-studied group of PG …

Peptidoglycan (PG) is an essential molecule for the survival of bacteria, and thus, its
biosynthesis and remodeling have always been in the spotlight when it comes to the …

Staphylococcus aureus is an important human and livestock pathogen that is well-protected
against environmental insults by a thick cell wall. Accordingly, the wall is a major target of …

Sophisticated mechanisms are employed to facilitate information exchange between
interfacing bacteria. A type VI secretion system (T6SS) of Pseudomonas aeruginosa was …

There is growing concern about the emergence of bacterial strains showing resistance to all
classes of antibiotics commonly used in human medicine. Despite the broad range of …

Phagocytes are crucial for host defense against bacterial pathogens. As first demonstrated
by Metchnikoff, neutrophils and mononuclear phagocytes share the capacity to engulf, kill …