Among all neurotrophins, brain-derived neurotrophic factor (BDNF) stands out for its high
level of expression in the brain and its potent effects on synapses. It is now widely accepted …

Scientific evidence based on neuroimaging approaches over the last decade has
demonstrated the efficacy of physical activity improving cognitive health across the human …

Exercise promotes learning and memory formation. These effects depend on increases in
hippocampal BDNF, a growth factor associated with cognitive improvement and the …

Increasing evidence suggests that synaptic dysfunction is a key pathophysiological hallmark
in neurodegenerative disorders, including Alzheimer's disease. Understanding the role of …

More than two hundred years after its discovery, lactate still remains an intriguing molecule.
Considered for a long time as a waste product of metabolism and the culprit behind …

The characteristic features of Alzheimer's disease (AD) are the appearance of extracellular
amyloid-beta (Aβ) plaques and neurofibrillary tangles in the intracellular environment …

Lynch, MA. Long-Term Potentiation and Memory. Physiol Rev 84: 87–136, 2004;
10.1152/physrev. 00014.2003.—One of the most significant challenges in neuroscience is to …

We found that a short exercise period enhanced cognitive function on the Morris water maze
(MWM), such that exercised animals were significantly better than sedentary controls at …

Since its discovery almost three decades ago, the secreted neurotrophin brain-derived
neurotrophic factor (BDNF) has been firmly implicated in the differentiation and survival of …

Hippocampal volume shrinks in late adulthood, but the neuromolecular factors that trigger
hippocampal decay in aging humans remains a matter of speculation. In rodents, brain …