Despite recent advances in the treatment of autoimmune and inflammatory diseases, unmet
medical needs in some areas still exist. One of the main therapeutic approaches to alleviate …

Lipid metabolism plays a major role in the regulation of the immune system. Exogenous
(dietary and microbial-derived) and endogenous (non-microbial-derived) lipids play a direct …

Mesenchymal cells are mesoderm-derived stromal cells that are best known for providing
structural support to organs, synthesizing and remodeling the extracellular matrix (ECM) and …

The initiation of an intestinal tumour is a probabilistic process that depends on the
competition between mutant and normal epithelial stem cells in crypts. Intestinal stem cells …

Fibrosis is a pathologic process characterized by the replacement of parenchymal tissue by
large amounts of extracellular matrix, which may lead to organ dysfunction and even death …

Intestinal stem and progenitor cells replicate and differentiate in distinct compartments,
influenced by Wnt, BMP, and other subepithelial cues. The cellular sources of these signals …

Pediatric-onset colitis and inflammatory bowel disease (IBD) have significant effects on the
growth of infants and children, but the etiopathogenesis underlying disease subtypes …

This review provides a concise summary of the changing phenotypes of macrophages and
fibroblastic cells during the local inflammatory response, the onset of tissue repair, and the …

The term fibroblast has been used generally to describe spindle-shaped stromal cells of
mesenchymal origin that produce extracellular matrix, establish tissue structure, and form …

Inflammatory bowel disease is characterized by defects in epithelial function and
dysregulated inflammatory signaling by lamina propria mononuclear cells including …