Molecular pathways of major depressive disorder converge on the synapse

GR Fries, VA Saldana, J Finnstein, T Rein - Molecular Psychiatry, 2023 - nature.com
Major depressive disorder (MDD) is a psychiatric disease of still poorly understood
molecular etiology. Extensive studies at different molecular levels point to a high complexity …

[HTML][HTML] The different autophagy degradation pathways and neurodegeneration

A Fleming, M Bourdenx, M Fujimaki, C Karabiyik… - Neuron, 2022 - cell.com
The term autophagy encompasses different pathways that route cytoplasmic material to
lysosomes for degradation and includes macroautophagy, chaperone-mediated autophagy …

Melatonin prevents neuroinflammation and relieves depression by attenuating autophagy impairment through FOXO3a regulation

T Ali, SU Rahman, Q Hao, W Li, Z Liu… - Journal of pineal …, 2020 - Wiley Online Library
Major depressive disorder (MDD) is a life‐threatening illness characterized by mood
changes and high rates of suicide. Although the role of neuroinflammation in MMD has been …

[HTML][HTML] Nrf2: An all-rounder in depression

C Zuo, H Cao, Y Song, Z Gu, Y Huang, Y Yang, J Miao… - Redox biology, 2022 - Elsevier
The balance between oxidation and antioxidant is crucial for maintaining homeostasis. Once
disrupted, it can lead to various pathological outcomes and diseases, such as depression …

Paeoniflorin: a neuroprotective monoterpenoid glycoside with promising anti-depressive properties

XL Wang, ST Feng, YT Wang, NH Chen, ZZ Wang… - Phytomedicine, 2021 - Elsevier
Background Depression, as a prevalent and debilitating psychiatric disease, severely
decreases the life quality of individuals and brings heavy burdens to the whole society …

The shared molecular mechanisms underlying aging of the brain, major depressive disorder, and Alzheimer's disease: The role of circadian rhythm disturbances

M Amidfar, ML Garcez, YK Kim - Progress in Neuro-Psychopharmacology …, 2023 - Elsevier
An association with circadian clock function and pathophysiology of aging, major depressive
disorder (MDD), and Alzheimer's disease (AD) is well established and has been proposed …

Increasing Nrf2 activity as a treatment approach in neuropsychiatry

G Morris, AJ Walker, K Walder, M Berk, W Marx… - Molecular …, 2021 - Springer
Nuclear factor erythroid 2-related factor 2 (Nrf2) is a transcription factor encoded by NFE2L2.
Under oxidative stress, Nrf2 does not undergo its normal cytoplasmic degradation but …

Potential antidepressant effects of Scutellaria baicalensis, Hericium erinaceus and Rhodiola rosea

F Limanaqi, F Biagioni, CL Busceti, M Polzella… - Antioxidants, 2020 - mdpi.com
Recent studies focused on the pharmacology and feasibility of herbal compounds as a
potential strategy to target a variety of human diseases ranging from metabolic to brain …

Antidepressant drug sertraline modulates AMPK-MTOR signaling-mediated autophagy via targeting mitochondrial VDAC1 protein

HY Hwang, JS Shim, D Kim, HJ Kwon - autophagy, 2021 - Taylor & Francis
ABSTRACT Macroautophagy/autophagy (hereafter autophagy), the process of mass
degradation of unnecessary elements within the cell, is often dysregulated in many diseases …

Altered extracellular mRNA communication in postpartum depression is associated with decreased autophagy

LM Osborne, JL Payne, ML Sherer… - Molecular psychiatry, 2022 - nature.com
We investigated whether extracellular RNA communication, which is a recently discovered
mode of intercellular communication that is involved in a variety of important biological …