Molecular pathways of major depressive disorder converge on the synapse
GR Fries, VA Saldana, J Finnstein, T Rein - Molecular Psychiatry, 2023 - nature.com
Major depressive disorder (MDD) is a psychiatric disease of still poorly understood
molecular etiology. Extensive studies at different molecular levels point to a high complexity …
molecular etiology. Extensive studies at different molecular levels point to a high complexity …
[HTML][HTML] The different autophagy degradation pathways and neurodegeneration
The term autophagy encompasses different pathways that route cytoplasmic material to
lysosomes for degradation and includes macroautophagy, chaperone-mediated autophagy …
lysosomes for degradation and includes macroautophagy, chaperone-mediated autophagy …
Melatonin prevents neuroinflammation and relieves depression by attenuating autophagy impairment through FOXO3a regulation
Major depressive disorder (MDD) is a life‐threatening illness characterized by mood
changes and high rates of suicide. Although the role of neuroinflammation in MMD has been …
changes and high rates of suicide. Although the role of neuroinflammation in MMD has been …
[HTML][HTML] Nrf2: An all-rounder in depression
C Zuo, H Cao, Y Song, Z Gu, Y Huang, Y Yang, J Miao… - Redox biology, 2022 - Elsevier
The balance between oxidation and antioxidant is crucial for maintaining homeostasis. Once
disrupted, it can lead to various pathological outcomes and diseases, such as depression …
disrupted, it can lead to various pathological outcomes and diseases, such as depression …
Paeoniflorin: a neuroprotective monoterpenoid glycoside with promising anti-depressive properties
XL Wang, ST Feng, YT Wang, NH Chen, ZZ Wang… - Phytomedicine, 2021 - Elsevier
Background Depression, as a prevalent and debilitating psychiatric disease, severely
decreases the life quality of individuals and brings heavy burdens to the whole society …
decreases the life quality of individuals and brings heavy burdens to the whole society …
The shared molecular mechanisms underlying aging of the brain, major depressive disorder, and Alzheimer's disease: The role of circadian rhythm disturbances
An association with circadian clock function and pathophysiology of aging, major depressive
disorder (MDD), and Alzheimer's disease (AD) is well established and has been proposed …
disorder (MDD), and Alzheimer's disease (AD) is well established and has been proposed …
Increasing Nrf2 activity as a treatment approach in neuropsychiatry
Nuclear factor erythroid 2-related factor 2 (Nrf2) is a transcription factor encoded by NFE2L2.
Under oxidative stress, Nrf2 does not undergo its normal cytoplasmic degradation but …
Under oxidative stress, Nrf2 does not undergo its normal cytoplasmic degradation but …
Potential antidepressant effects of Scutellaria baicalensis, Hericium erinaceus and Rhodiola rosea
F Limanaqi, F Biagioni, CL Busceti, M Polzella… - Antioxidants, 2020 - mdpi.com
Recent studies focused on the pharmacology and feasibility of herbal compounds as a
potential strategy to target a variety of human diseases ranging from metabolic to brain …
potential strategy to target a variety of human diseases ranging from metabolic to brain …
Antidepressant drug sertraline modulates AMPK-MTOR signaling-mediated autophagy via targeting mitochondrial VDAC1 protein
HY Hwang, JS Shim, D Kim, HJ Kwon - autophagy, 2021 - Taylor & Francis
ABSTRACT Macroautophagy/autophagy (hereafter autophagy), the process of mass
degradation of unnecessary elements within the cell, is often dysregulated in many diseases …
degradation of unnecessary elements within the cell, is often dysregulated in many diseases …
Altered extracellular mRNA communication in postpartum depression is associated with decreased autophagy
LM Osborne, JL Payne, ML Sherer… - Molecular psychiatry, 2022 - nature.com
We investigated whether extracellular RNA communication, which is a recently discovered
mode of intercellular communication that is involved in a variety of important biological …
mode of intercellular communication that is involved in a variety of important biological …