Proprotein convertase subtilisin/kexin type 9 (PCSK9), mainly synthetized and released by
the liver, represents one of the key regulators of low-density lipoprotein cholesterol …

Characterized as a chronic inflammatory disease of the large arteries, atherosclerosis is the
primary cause of cardiovascular disease, the leading contributor of morbidity and mortality …

Cardiovascular disease (CVD) remains the leading cause of death and disability worldwide.
While many factors can contribute to CVD, atherosclerosis is the cardinal underlying …

According to the WHO, the entire global population is exposed to air pollution levels higher
than recommended for health preservation. Air pollution is a complex mixture of nano-to …

Atherosclerotic cardiovascular disease (ASCVD) remains a leading cause of morbidity and
mortality despite excellent pharmacological and revascularization approaches. Low-density …

Inflammation is an obligatory marker of arterial disease, both stemming from the
inflammatory activity of cholesterol itself and from well-established molecular mechanisms …

Background: Both PCSK9 and NLRP3 inflammasome play important roles in atherogenesis.
This study was designed to test the hypothesis that NLRP3 inflammasome via IL-1β induces …

Platelets play a significant role in atherothrombosis. Proprotein convertase subtilisin/kexin
type 9 (PCSK9) is critically involved in the regulation of LDL metabolism and interacts with …

Regulation of pro-protein convertase subtilisin/kexin type 9 (PCSK9) by drugs has led to the
development of a still small number of agents with powerful activity on low-density …

Fine particulate matter (PM2. 5) air pollution exposure increases the risk of develo**
cardiovascular disease (CVD). Although the precise mechanisms by which air pollution …