Transient receptor potential (TRP) channels are sensors for a variety of cellular and
environmental signals. Mammals express a total of 28 different TRP channel proteins, which …

The transient receptor potential vanilloid-1 (TRPV1) is a non-specific cation channel known
for its sensitivity to pungent vanilloid compound (ie capsaicin) and noxious stimuli, including …

Migraine is a chronic neurological disorder that affects approximately 12% of the population.
The cause of migraine headaches is not yet known, however, when the trigeminal system is …

Transient receptor potential vanilloid 1 (TRPV1) channels are widely distributed in sensory
nerve endings, the central nervous system, and other tissues, functioning as ion channel …

Obesity is a significant health concern that often leads to metabolic dysfunction and chronic
diseases. This study introduces a novel approach to combat obesity using orally ingested …

Chronic pain is a common symptom experienced during cancer progression. Additionally,
some patients experience bone pain caused by cancer metastasis, which further …

Chronic pain and pruritus are highly disabling pathologies that still lack appropriate
therapeutic intervention. At cellular level the transduction and transmission of pain and …

Osteoarthritis (OA) is a highly prevalent joint disease that causes substantial disability, yet
effective approaches to disease prevention or to the delay of OA progression are lacking …

Chronic pain is a major burden for the society and remains more prevalent and severe in
females. The presence of chronic pain is linked to persistent alterations in the peripheral and …

Introduction Thermo transient receptor potential (thermoTRP) channels are some of the most
intensely pursued therapeutic targets of the past decade. They are considered promising …