Neuronal migration is, along with axon guidance, one of the fundamental mechanisms
underlying the wiring of the brain. As other organs, the nervous system has acquired the …

Microtubules are fibrous elements in the cytoplasm of eukaryotic cells, where they perform a
wide variety of functions. Microtubules are major organizers of the cell interior and are vitally …

Bulk matrix stiffness has emerged as a key mechanical cue in stem cell differentiation. Here,
we show that the commitment and differentiation of human mesenchymal stem cells …

The hippocampal expression profiles of wild-type mice and mice transgenic for δC-
doublecortin-like kinase were compared with Solexa/Illumina deep sequencing technology …

Background & Aims As in other tumor types, progression of pancreatic cancer may require a
functionally unique population of cancer stem cells. Although such cells have been identified …

To better understand the molecular mechanisms governing oligodendrocyte (OL)
differentiation, we have used gene profiling to quantitatively analyze gene expression in …

In the gut, tumorigenesis arises from intestinal or colonic crypt stem cells. Currently, no
definitive markers exist that reliably identify gut stem cells. Here, we used the putative stem …

Although mutations in the human doublecortin gene (DCX) cause profound defects in
cortical neuronal migration, a genetic deletion of Dcx in mice produces a milder defect. A …

Neurons undertake an amazing journey from the center of the develo** mammalian brain
to the outer layers of the cerebral cortex. Doublecortin, a component of the microtubule …

Doublecortin (DCX) is a microtubule-associated protein that is required for normal
neocortical and hippocampal development in humans. Mutations in the X-linked human …