Chronic use of drugs of abuse results in neurochemical, morphological and behavioral
plasticity that underlies the emergence of compulsive drug seeking and vulnerability to …

Substance addiction is a chronic and relapsing brain disorder characterized by compulsive
seeking and continued substance use, despite adverse consequences. The high prevalence …

Exposure to early life adversity can predispose adolescents to the formation of substance
abuse disorders. In rodents, early stressors such as repeated maternal separation (MS) …

Recovery from opioid use disorder (OUD) and maintenance of abstinence from opioid use is
hampered by perseverant drug cravings that may persist for months after cessation of drug …

Obesity is damaging the lives of more than 300 million people worldwide and maintaining a
healthy weight using popular weight loss tactics remains a very difficult undertaking …

Healthy persons hold a very complex system for controlling energy homeostasis. The system
functions on the interconnected way between the nutritional, endocrine, neural, and …

Exposure to intermittent repeated social defeat (IRSD) increases the vulnerability of mice to
the rewarding effects of cocaine in the conditioned place preference (CPP) paradigm …

The development of substance abuse problems occurs due to a diverse combination of risk
factors. Among these risks, studies have reported depression and early-life stress as of …

Drug addiction is a devastating disorder with a huge economic and social burden for
modern society. Although an individual may slip into drug abuse throughout his/her life …

Abstract Toll-like Receptors (TLRs) are implicated with the pathogenesis of cognitive
impairment induced by inflammation. Early life stress is associated with altered trajectories …