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The NLRP3 inflammasome and COVID-19: Activation, pathogenesis and therapeutic strategies
N Zhao, B Di, L Xu - Cytokine & growth factor reviews, 2021 - Elsevier
Abstract Coronavirus disease 2019 (COVID-19), caused by severe acute respiratory
syndrome coronavirus 2 (SARS-CoV-2), exhibits a wide spectrum of clinical presentations …
syndrome coronavirus 2 (SARS-CoV-2), exhibits a wide spectrum of clinical presentations …
Bacterial lipopolysaccharide-induced endothelial activation and dysfunction: a new predictive and therapeutic paradigm for sepsis
M Wang, J Feng, D Zhou, J Wang - European Journal of Medical Research, 2023 - Springer
Background Lipopolysaccharide, a highly potent endotoxin responsible for severe sepsis, is
the major constituent of the outer membrane of gram-negative bacteria. Endothelial cells …
the major constituent of the outer membrane of gram-negative bacteria. Endothelial cells …
The prospective effect of allopurinol on the oxidative stress index and endothelial dysfunction in Covid-19
SARS-CoV-2 by the direct cytopathic effect or indirectly through the propagation of pro-
inflammatory cytokines could cause endothelial dysfunction (ED) and oxidative stress (OS) …
inflammatory cytokines could cause endothelial dysfunction (ED) and oxidative stress (OS) …
[HTML][HTML] Atypical response to bacterial coinfection and persistent neutrophilic bronchoalveolar inflammation distinguish critical COVID-19 from influenza
Neutrophils are recognized as important circulating effector cells in the pathophysiology of
severe coronavirus disease 2019 (COVID-19). However, their role within the inflamed lungs …
severe coronavirus disease 2019 (COVID-19). However, their role within the inflamed lungs …
Melatonin: highlighting its use as a potential treatment for SARS-CoV-2 infection
Numerous pharmaceutical drugs have been repurposed for use as treatments for COVID-19
disease. These drugs have not consistently demonstrated high efficacy in preventing or …
disease. These drugs have not consistently demonstrated high efficacy in preventing or …
[HTML][HTML] Metformin to decrease COVID-19 severity and mortality: Molecular mechanisms and therapeutic potential
The COVID-19 pandemic caused by the coronavirus SARS-CoV-2 has become a serious
challenge for medicine and science. Analysis of the molecular mechanisms associated with …
challenge for medicine and science. Analysis of the molecular mechanisms associated with …
[HTML][HTML] SARS-CoV-2 infection causes dopaminergic neuron senescence
COVID-19 patients commonly present with signs of central nervous system and/or peripheral
nervous system dysfunction. Here, we show that midbrain dopamine (DA) neurons derived …
nervous system dysfunction. Here, we show that midbrain dopamine (DA) neurons derived …
NLRP3 Inflammasome: a key contributor to the inflammation formation
WJ Zhang, KY Li, Y Lan, HY Zeng, SQ Chen… - Food and Chemical …, 2023 - Elsevier
Inflammation is an important part of the development of various organ diseases. The
inflammasome, as an innate immune receptor, plays an important role in the formation of …
inflammasome, as an innate immune receptor, plays an important role in the formation of …
[HTML][HTML] NLRP3 inflammasome activation and SARS-CoV-2-mediated hyperinflammation, cytokine storm and neurological syndromes
Despite the introduction of vaccines and drugs for SARS-CoV-2, the COVID-19 pandemic
continues to spread throughout the world. In severe COVID-19 patients, elevated levels of …
continues to spread throughout the world. In severe COVID-19 patients, elevated levels of …
[HTML][HTML] Cell-membrane-coated nanoparticles for the fight against pathogenic bacteria, toxins, and inflammatory cytokines associated with sepsis
Sepsis is the main cause of death in patients suffering from serious illness. Yet, there is still
no specific treatment for sepsis, and management relies on infection control. Cell membrane …
no specific treatment for sepsis, and management relies on infection control. Cell membrane …