Vanadium in biological action: chemical, pharmacological aspects, and metabolic implications in diabetes mellitus

S Treviño, A Díaz, E Sánchez-Lara… - Biological trace element …, 2019 - Springer
Vanadium compounds have been primarily investigated as potential therapeutic agents for
the treatment of various major health issues, including cancer, atherosclerosis, and …

Speciation of metal drugs, supplements and toxins in media and bodily fluids controls in vitro activities

A Levina, DC Crans, PA Lay - Coordination Chemistry Reviews, 2017 - Elsevier
Studies of metal uptake, metabolism and excretion by single bacterial, yeast, plant and
animal cells is a widespread area of research, yet little is known about the reactivity and …

Hydrolysis, Ligand Exchange, and Redox Properties of Vanadium Compounds: Implications of Solution Transformation on Biological, Therapeutic, and Environmental …

R Dinda, E Garribba, D Sanna, DC Crans… - Chemical …, 2025 - ACS Publications
Vanadium is a transition metal with important industrial, technological, biological, and
biomedical applications widespread in the environment and in living beings. The different …

Decavanadate (V10O286-) and oxovanadates: Oxometalates with many biological activities

M Aureliano, DC Crans - Journal of inorganic biochemistry, 2009 - Elsevier
The decameric vanadate species V10O286-, also referred to as decavanadate, impact
proteins, lipid structures and cellular function, and show some effects in vivo on oxidative …

Anti-diabetic effects of a series of vanadium dipicolinate complexes in rats with streptozotocin-induced diabetes

GR Willsky, LH Chi, M Godzala III, PJ Kostyniak… - Coordination Chemistry …, 2011 - Elsevier
The effects of oral treatment of rats with streptozotocin-induced diabetes with a range of
vanadium dipicolinate complexes (Vdipic) and derivatives are reviewed. Structure–reactivity …

Antidiabetic, chemical, and physical properties of organic vanadates as presumed transition-state inhibitors for phosphatases

DC Crans - The Journal of Organic Chemistry, 2015 - ACS Publications
Studies of antidiabetic vanadium compounds, specifically the organic vanadate esters, are
reviewed with regard to their chemistry and biological properties. The compounds are …

Vanadium compounds induced mitochondria permeability transition pore (PTP) opening related to oxidative stress

Y Zhao, L Ye, H Liu, Q **a, Y Zhang, X Yang… - Journal of inorganic …, 2010 - Elsevier
Vanadium compounds have been regarded as promising in therapeutic treatment of
diabetes and in cancer prevention. In the present work, we studied the effects of vanadium …

Why antidiabetic vanadium complexes are not in the pipeline of “big pharma” drug research? A critical review

T Scior, J Antonio Guevara-Garcia… - Current medicinal …, 2016 - ingentaconnect.com
Public academic research sites, private institutions as well as small companies have made
substantial contributions to the ongoing development of antidiabetic vanadium compounds …

[HTML][HTML] Decavanadate and metformin-decavanadate effects in human melanoma cells

AL De Sousa-Coelho, M Aureliano, G Fraqueza… - Journal of Inorganic …, 2022 - Elsevier
Decavanadate is a polyoxometalate (POMs) that has shown extensive biological activities,
including antidiabetic and anticancer activity. Importantly, vanadium-based compounds as …

Vanadium stimulates pepper plant growth and flowering, increases concentrations of amino acids, sugars and chlorophylls, and modifies nutrient concentrations

A García-Jiménez, LI Trejo-Téllez, D Guillén-Sánchez… - Plos one, 2018 - journals.plos.org
Vanadium (V) can be absorbed by plants and regulate their growth and development,
although contrasting effects have been reported among species and handling conditions …