For more than a decade, numerous studies have suggested that the c-Myc oncogenic
protein is likely to broadly influence the composition of the transcriptome. However, the …

Deregulation of the cell cycle underlies the aberrant cell proliferation that characterizes
cancer and loss of cell cycle checkpoint control promotes genetic instability. During the past …

The development of an oncogenic state is a complex process involving the accumulation of
multiple independent mutations that lead to deregulation of cell signalling pathways central …

Introduction Breast cancer subty** and prognosis have been studied extensively by gene
expression profiling, resulting in disparate signatures with little overlap in their constituent …

Activation in transformed cells of normal stem cells' self-renewal pathways might contribute
to the survival life cycle of cancer stem cells and promote tumor progression. The BMI-1 …

Based on the hypothesis that features of the molecular program of normal wound healing
might play an important role in cancer metastasis, we previously identified consistent …

Motivation: Classification and feature selection of genomics or transcriptomics data is often
hampered by the large number of features as compared with the small number of samples …

High-throughput genomic and proteomic technologies are widely used in cancer research to
build better predictive models of diagnosis, prognosis and therapy, to identify and …

Therapies for patients with cancer have changed gradually over the past decade, moving
away from the administration of broadly acting cytotoxic drugs towards the use of more …

The exponential growth of biomedical data in recent years has urged the application of
numerous machine learning techniques to address emerging problems in biology and …