Aldehyde dehydrogenase (ALDH) is a superfamily of enzymes that detoxify a variety of
endogenous and exogenous aldehydes and are required for the biosynthesis of retinoic …

The common and persistent failures to translate promising preclinical drug candidates into
clinical success highlight the limited effectiveness of disease models currently used in drug …

Mesenchymal stem cells (MSC) are known to facilitate healing of ischemic tissue related
diseases through proangiogenic secretory proteins. Recent studies further show that MSC …

Proteomes are characterized by large protein-abundance differences, cell-type-and time-
dependent expression patterns and post-translational modifications, all of which carry …

MicroRNAs (miRNAs) are short, noncoding RNAs that regulate gene expression by
suppressing mRNA translation and reducing mRNA stability. A miRNA can potentially bind …

Retinoids regulate a wide spectrum of cellular functions from the embryo throughout
adulthood, including cell differentiation, metabolic regulation, and inflammation. These traits …

Aldehyde dehydrogenases (ALDHs), as essential regulators of aldehyde metabolism in the
human body, protect organisms from damage induced by active aldehydes. Given their roles …

Identification of effective prognostic biomarkers and targets are of crucial importance to the
management of breast cancer. CCNB1 (also known as CyclinB1) belongs to the highly …

Transcription factors (TFs), transcription co-factors (TcoFs) and their target genes perform
essential functions in diseases and biological processes. KnockTF 2.0 (http://www …

All-trans retinoic acid (ATRA) is the most important active metabolite of vitamin A controlling
segmentation in the develo** organism and the homeostasis of various tissues in the …