A majority of humans faced with severe stress maintain normal physiological and behavioral
function, a process referred to as resilience. Such stress resilience has been modeled in …

The locus coeruleus (LC) is a small nucleus in the pons from which ascending and
descending projections innervate major parts of the central nervous system. Its major …

Stressful events, from daily stressors to traumatic experiences, are common and occur at any
age. Despite the high prevalence of trauma, not everyone develops stress-related disorders …

Major depressive disorder (MDD) is a serious disease and a burden to patients, families and
society. Rodent experiments and human studies suggest that several neuropeptide systems …

Maternal separation (MS), a form of early life adversity, increases the risk of psychiatric
disorders in adulthood by intricately linking cytokines and mood-regulating brain circuits …

Introduction Transcriptomic studies offer valuable insights into the pathophysiology of
traumatic stress-induced neuropsychiatric disorders, including generalized anxiety disorder …

Stress is a primary risk factor for psychiatric disorders such as Major Depressive Disorder
(MDD) and Post Traumatic Stress Disorder (PTSD). The response to stress involves the …

Preclinical and clinical work has demonstrated altered plasticity and activity in the nucleus
accumbens (NAc) under chronic pain states, highlighting critical therapeutic avenues for the …

The experience of traumatic stress can engender lasting memories associated with the
trauma, often resulting in post-traumatic stress disorder (PTSD). However, only a minority of …

Wild orangutans (Pongo spp.) rescued from human-wildlife conflict must be adequately
rehabilitated before being returned to the wild. It is essential that released orangutans are …