The roles of matrix metalloproteinases and their inhibitors in human diseases
Matrix metalloproteinases (MMPs) are a family of zinc-dependent extracellular matrix (ECM)
remodeling endopeptidases that have the capacity to degrade almost every component of …
remodeling endopeptidases that have the capacity to degrade almost every component of …
Matrix metalloproteinases (MMPs), the main extracellular matrix (ECM) enzymes in collagen degradation, as a target for anticancer drugs
The main group of enzymes responsible for the collagen and other protein degradation in
extracellular matrix (ECM) are matrix metalloproteinases (MMPs). Collagen is the main …
extracellular matrix (ECM) are matrix metalloproteinases (MMPs). Collagen is the main …
Tumor metastasis: mechanistic insights and clinical challenges
PS Steeg - Nature medicine, 2006 - nature.com
Metastatic disease is the primary cause of death for most cancer patients. Complex and
redundant pathways involving the tumor cell and the microenvironment mediate tumor …
redundant pathways involving the tumor cell and the microenvironment mediate tumor …
Matrix metalloproteinases and tumor metastasis
EI Deryugina, JP Quigley - Cancer and metastasis reviews, 2006 - Springer
Functions of individual matrix metalloproteinases (MMPs) differentially expressed by tumor
cells and stromal cells, are finely regulated by their spatial as well as temporal interactions …
cells and stromal cells, are finely regulated by their spatial as well as temporal interactions …
Host response mechanisms in periodontal diseases
N Silva, L Abusleme, D Bravo, N Dutzan… - Journal of Applied Oral …, 2015 - SciELO Brasil
Periodontal diseases usually refer to common inflammatory disorders known as gingivitis
and periodontitis, which are caused by a pathogenic microbiota in the subgingival biofilm …
and periodontitis, which are caused by a pathogenic microbiota in the subgingival biofilm …
Matrix metalloproteinases in the brain and blood–brain barrier: versatile breakers and makers
Matrix metalloproteinases are versatile endopeptidases with many different functions in the
body in health and disease. In the brain, matrix metalloproteinases are critical for tissue …
body in health and disease. In the brain, matrix metalloproteinases are critical for tissue …
Matrix metalloproteinases: contribution to pathogenesis, diagnosis and treatment of periodontal inflammation
T Sorsa, L Tjäderhane, YT Konttinen, A Lauhio… - Annals of …, 2006 - Taylor & Francis
Matrix metalloproteinases (MMPs) form a family of enzymes that mediate multiple functions
both in the tissue destruction and immune responses related to periodontal inflammation …
both in the tissue destruction and immune responses related to periodontal inflammation …
[HTML][HTML] Matrix metalloproteinases: evolution, gene regulation and functional analysis in mouse models
Matrix metalloproteinases (MMPs) are a large family of zinc-endopeptidases which play
important roles in multiple physiological and pathological processes. These enzymes are …
important roles in multiple physiological and pathological processes. These enzymes are …
[HTML][HTML] Matrix metalloproteinases: what do they not do? New substrates and biological roles identified by murine models and proteomics
D Rodríguez, CJ Morrison, CM Overall - Biochimica et Biophysica Acta …, 2010 - Elsevier
The biological roles of the matrix metalloproteinases (MMPs) have been traditionally
associated with the degradation and turnover of most of the components of the extracellular …
associated with the degradation and turnover of most of the components of the extracellular …
Matrix metalloproteinases as regulators of periodontal inflammation
Periodontitis are infectious diseases characterized by immune-mediated destruction of
periodontal supporting tissues and tooth loss. Matrix metalloproteinases (MMPs) are key …
periodontal supporting tissues and tooth loss. Matrix metalloproteinases (MMPs) are key …