The concept of using mRNA to produce its own medicine in situ in the body makes it an ideal
drug candidate, holding great potential to revolutionize the way we approach medicine. The …

Atherosclerosis, a chronic disease associated with metabolism, poses a significant risk to
human well‐being. Currently, existing treatments for atherosclerosis lack sufficient efficiency …

Lung cancer is the second most common cancer and the leading cause of death in both men
and women in the world. Lung cancer is heterogeneous in nature and diagnosis is often at …

Abstract mRNA‐based therapeutics are a unique class of drugs for treatment of human
diseases. Since in vitro transcribed mRNA molecules have relatively low stability and their …

For the longest time, the field of nucleic acid delivery has remained skeptical whether or not
polycationic drug carrier systems would ever make it into clinical practice. Yet, with the …

Gene therapy for neurological disorders has attracted significant interest as a way to reverse
or stop various disease pathologies. Typical gene therapies involving the central and …

Endothelial cells (ECs) are an important target for therapy in a wide range of diseases, most
notably atherosclerosis. Develo** efficient nanoparticle (NP) systems that deliver RNA …

Polyplex-mediated gene transfection is now in its' fourth decade of serious research, but the
promise of polyplex-mediated gene therapy has yet to fully materialize. Only approximately …

In this work, a pH-sensitive liposome–polymer nanoparticle (NP) composed of lipid,
hyaluronic acid (HA) and poly (β-amino ester)(PBAE) was prepared using layer-by-layer …

The co-assembly of ionic-neutral block copolymers with oppositely charged species
produces nanometric colloidal complexes, known, among other names, as complex …