Natural products inhibitors of monoamine oxidases—Potential new drug leads for neuroprotection, neurological disorders, and neuroblastoma
Monoamine oxidase inhibitors (MAOIs) are an important class of drugs prescribed for
treatment of depression and other neurological disorders. Evidence has suggested that …
treatment of depression and other neurological disorders. Evidence has suggested that …
Neuroprotective function of rasagiline and selegiline, inhibitors of type B monoamine oxidase, and role of monoamine oxidases in synucleinopathies
M Naoi, W Maruyama, M Shamoto-Nagai - International Journal of …, 2022 - mdpi.com
Synucleinopathies are a group of neurodegenerative disorders caused by the accumulation
of toxic species of α-synuclein. The common clinical features are chronic progressive …
of toxic species of α-synuclein. The common clinical features are chronic progressive …
Mitochondrial-targeted and near-infrared fluorescence probe for bioimaging and evaluating monoamine oxidase A activity in hepatic fibrosis
ZM Yang, QY Mo, JM He, DL Mo, J Li, H Chen… - ACS …, 2020 - ACS Publications
Monoamine oxidase A (MAO-A) is a promising diagnostic marker for cancer, depression,
Parkinson's disease, and liver disease. The fluorescence detection of MAO-A in living …
Parkinson's disease, and liver disease. The fluorescence detection of MAO-A in living …
Calcineurin inhibition protects against dopamine toxicity and attenuates behavioral decline in a Parkinson's disease model
R Mondal, C Banerjee, S Nandy, M Roy… - Cell & Bioscience, 2023 - Springer
Background Parkinson's disease (PD), a highly prevalent neuro-motor disorder is caused
due to progressive loss of dopaminergic (DAergic) neurons at substantia nigra region of …
due to progressive loss of dopaminergic (DAergic) neurons at substantia nigra region of …
Myricitrin–a flavonoid isolated from the Indian olive tree (Elaeocarpus floribundus)–inhibits Monoamine oxidase in the brain and elevates striatal dopamine levels …
Flavonoids exhibit several biological activities including inhibition of Monoamine oxidase
(MAO), an enzyme that metabolizes several neurotransmitters. Thus, MAO inhibitors are well …
(MAO), an enzyme that metabolizes several neurotransmitters. Thus, MAO inhibitors are well …
Recent advances on the role of monoamine oxidases in cardiac pathophysiology
N Kaludercic, RJ Arusei, F Di Lisa - Basic Research in Cardiology, 2023 - Springer
Numerous physiological and pathological roles have been attributed to the formation of
mitochondrial reactive oxygen species (ROS). However, the individual contribution of …
mitochondrial reactive oxygen species (ROS). However, the individual contribution of …
Monoamine oxidase-dependent pro-survival signaling in diabetic hearts is mediated by miRNAs
S Cagnin, M Brugnaro, C Millino, B Pacchioni… - Cells, 2022 - mdpi.com
Diabetes leads to cardiomyopathy and heart failure, the leading cause of death for diabetic
patients. Monoamine oxidase (MAO) inhibition in diabetic cardiomyopathy prevents …
patients. Monoamine oxidase (MAO) inhibition in diabetic cardiomyopathy prevents …
Induction of monoamine oxidase A-mediated oxidative stress and impairment of NRF2-antioxidant defence response by polyphenol-rich fraction of Bergenia ligulata …
Prostate cancer (PCa) is a major cause of mortality and morbidity in men. Available
therapies yield limited outcome. We explored anti-PCa activity in a polyphenol-rich fraction …
therapies yield limited outcome. We explored anti-PCa activity in a polyphenol-rich fraction …
IL-13 and the hydroperoxy fatty acid 13 (S) HpODE play crucial role in inducing an apoptotic pathway in cancer cells involving MAO-A/ROS/p53/p21 signaling axis
This study depicted the effect of IL-13 and 13 (S) HpODE (the endogenous product during IL-
13 activation) in the process of cancer cell apoptosis. We examined the role of both IL-13 …
13 activation) in the process of cancer cell apoptosis. We examined the role of both IL-13 …
Toxic interactions between dopamine, α-synuclein, monoamine oxidase, and genes in mitochondria of Parkinson's disease
M Naoi, W Maruyama, M Shamoto-Nagai… - Journal of Neural …, 2024 - Springer
Parkinson's disease is characterized by its distinct pathological features; loss of dopamine
neurons in the substantia nigra pars compacta and accumulation of Lewy bodies and Lewy …
neurons in the substantia nigra pars compacta and accumulation of Lewy bodies and Lewy …