The ubiquitin system is complex, multifaceted, and is crucial for the modulation of a vast
number of cellular processes. Ubiquitination is tightly regulated at different levels by a range …

Tumor necrosis factor alpha (TNF; TNFα) is a critical regulator of immune responses in
healthy organisms and in disease. TNF is involved in the development and proper …

Protein ubiquitination is a dynamic multifaceted post-translational modification involved in
nearly all aspects of eukaryotic biology. Once attached to a substrate, the 76-amino acid …

The master pro-inflammatory cytokine, tumour necrosis factor (TNF), has been shown to
modulate multiple signalling pathways, with wide-ranging downstream effects. TNF plays a …

Protein ubiquitination is one of the most powerful posttranslational modifications of proteins,
as it regulates a plethora of cellular processes in distinct manners. Simple …

TNF is a pleiotropic cytokine with important functions in homeostasis and disease
pathogenesis. Recent discoveries have provided insights into TNF biology that introduce …

Cells must adapt to changes in their environment to maintain cell, tissue and organismal
integrity in the face of mechanical, chemical or microbiological stress. Nuclear factor-κB (NF …

Ubiquitylation is an essential post-translational modification that regulates intracellular
signalling networks by triggering proteasomal substrate degradation, changing the activity of …

Tumor necrosis factor receptor (TNFR)-associated factors (TRAFs) are a family of structurally
related proteins that transduces signals from members of TNFR superfamily and various …

The NF-κB family of inducible transcription factors is activated in response to a variety of
stimuli. Amongst the best-characterized inducers of NF-κB are members of the TNF family of …