Towards an understanding of psychedelic-induced neuroplasticity

AE Calder, G Hasler - Neuropsychopharmacology, 2023 - nature.com
Classic psychedelics, such as LSD, psilocybin, and the DMT-containing beverage
ayahuasca, show some potential to treat depression, anxiety, and addiction. Importantly …

[HTML][HTML] Pharmacological, neural, and psychological mechanisms underlying psychedelics: A critical review

M van Elk, DB Yaden - Neuroscience & Biobehavioral Reviews, 2022 - Elsevier
This paper provides a critical review of several possible mechanisms at different levels of
analysis underlying the effects and therapeutic potential of psychedelics. At the (1) …

Serotonin 2A Receptor (5-HT2AR) Agonists: Psychedelics and Non-Hallucinogenic Analogues as Emerging Antidepressants

W Duan, D Cao, S Wang, J Cheng - Chemical Reviews, 2023 - ACS Publications
Psychedelics make up a group of psychoactive compounds that induce hallucinogenic
effects by activating the serotonin 2A receptor (5-HT2AR). Clinical trials have demonstrated …

[HTML][HTML] Psychedelics and neuroplasticity: a systematic review unraveling the biological underpinnings of psychedelics

CMH De Vos, NL Mason, KPC Kuypers - Frontiers in psychiatry, 2021 - frontiersin.org
Clinical studies suggest the therapeutic potential of psychedelics, including ayahuasca,
DMT, psilocybin, and LSD, in stress-related disorders. These substances induce cognitive …

Direct comparison of the acute effects of lysergic acid diethylamide and psilocybin in a double-blind placebo-controlled study in healthy subjects

F Holze, L Ley, F Müller, AM Becker… - …, 2022 - nature.com
Growing interest has been seen in using lysergic acid diethylamide (LSD) and psilocybin in
psychiatric research and therapy. However, no modern studies have evaluated differences …

Acute effects of psilocybin after escitalopram or placebo pretreatment in a randomized, double‐blind, placebo‐controlled, crossover study in healthy subjects

AM Becker, F Holze, T Grandinetti… - Clinical …, 2022 - Wiley Online Library
The psychedelic psilocybin is being investigated for the treatment of depression and anxiety.
Unclear is whether antidepressant treatments interact with psilocybin. The present study …

Acute effects of intravenous DMT in a randomized placebo-controlled study in healthy participants

SB Vogt, L Ley, L Erne, I Straumann, AM Becker… - Translational …, 2023 - nature.com
Abstract N, N-dimethyltryptamine (DMT) is distinct among classic serotonergic psychedelics
because of its short-lasting effects when administered intravenously. Despite growing …

Acute dose-dependent effects of lysergic acid diethylamide in a double-blind placebo-controlled study in healthy subjects

F Holze, P Vizeli, L Ley, F Müller, P Dolder… - …, 2021 - nature.com
Growing interest has been seen in using lysergic acid diethylamide (LSD) in psychiatric
research and therapy. However, no modern studies have evaluated subjective and …

Psychedelics and neural plasticity: therapeutic implications

SF Grieco, E Castrén, GM Knudsen, AC Kwan… - Journal of …, 2022 - jneurosci.org
Psychedelic drugs have reemerged as tools to treat several brain disorders. Cultural
attitudes toward them are changing, and scientists are once again investigating the neural …

Psychedelics in psychiatry: neuroplastic, immunomodulatory, and neurotransmitter mechanisms

A Inserra, D De Gregorio, G Gobbi - Pharmacological Reviews, 2021 - Elsevier
Mounting evidence suggests safety and efficacy of psychedelic compounds as potential
novel therapeutics in psychiatry. Ketamine has been approved by the Food and Drug …