Protein posttranslational modifications (PTMs) refer to the breaking or generation of covalent
bonds on the backbones or amino acid side chains of proteins and expand the diversity of …

The metabolism of glucose and lipids is essential for energy production in the body, and
dysregulation of the metabolic pathways of these molecules is implicated in various acute …

Paraquat is a quaternary nitrogen herbicide evoking mitochondrial damage and heart failure
with little therapeutic remedies available. Recent reports depicted a role for unchecked …

The Keap1-Nrf2 signaling pathway plays a crucial role in cellular defense against oxidative
stress-induced damage. Its activation entails the expression and transcriptional regulation of …

ABSTRACT α-Synuclein (α-Syn) aggregation in Lewy bodies and Lewy neurites has
emerged as a key pathogenetic feature in Parkinson's disease, dementia with Lewy bodies …

Simple Summary Mitochondria are crucially important organelles involved in various
metabolic activities, including energy generation. The involvement of mitochondrial …

Kidney diseases are serious health problems affecting> 800 million individuals worldwide.
The high number of affected individuals and the severe consequences of kidney dysfunction …

Lysine methylation is an abundant posttranslational modification, which has been most
intensively studied in the context of histone proteins, where it represents an important …

The biological mechanisms underlying the development of myopia have not yet been
completely elucidated. The retina is critical for visual signal processing, which primarily …

Proteins frequently undergo covalent modification at the post-translational level, which
involves the covalent attachment of chemical groups onto amino acids. This can entail the …