Evolvability is the ability of a biological system to produce phenotypic variation that is both
heritable and adaptive. It has long been the subject of anecdotal observations and …

Constraint-based reconstruction and analysis (COBRA) methods at the genome scale have
been under development since the first whole-genome sequences appeared in the mid …

Enzyme turnover numbers (k cat) are key to understanding cellular metabolism, proteome
allocation and physiological diversity, but experimentally measured k cat data are sparse …

Genome-scale metabolic models are instrumental in uncovering operating principles of
cellular metabolism, for model-guided re-engineering, and unraveling cross-feeding in …

Figure 1 iML1515 genome-scale reconstruction.(a) The iML1515 model contains 1,515
open reading frames that encode enzymes that catalyze 2,719 reactions involving 1,192 …

Antimicrobial peptides are promising alternative antimicrobial agents. However, little is
known about whether resistance to small-molecule antibiotics leads to cross-resistance …

The quantum nature of electrons and nuclei is manifested in countless biological events
including the rearrangements of electrons in biochemical reactions, electron and proton …

Antimicrobial peptides (AMPs) are promising antimicrobials, however, the potential of
bacterial resistance is a major concern. Here we systematically study the evolution of …

Both targeted and untargeted mass spectrometry-based metabolomics approaches are used
to understand the metabolic processes taking place in various organisms, from prokaryotes …

Unculturable bacterial communities provide a rich source of biocatalysts, but their
experimental discovery by functional metagenomics is difficult, because the odds are …