Irisin, out-membrane part of fibronectin type III domain–containing 5 protein (FNDC5), was
activated by Peroxisome proliferator-activated receptor γ (PPARγ) coactivator-1α (PGC-1α) …

Despite strong scientific evidence supporting the benefits of regular exercise for the
prevention and management of cardiovascular disease (CVD), physical inactivity is highly …

Defective brain hormonal signaling has been associated with Alzheimer's disease (AD), a
disorder characterized by synapse and memory failure. Irisin is an exercise-induced …

Sepsis-associated encephalopathy (SAE) is a common complication of severe sepsis. Irisin
is a novel exercise-induced myokine involved in the regulation of adipose browning and …

Irisin is secreted by muscle, increases with exercise, and mediates certain favorable effects
of physical activity. In particular, irisin has been shown to have beneficial effects in adipose …

Brown adipose tissue (BAT) displays the unique capacity to generate heat through
uncoupled oxidative phosphorylation that makes it a very attractive therapeutic target for …

Traditionally, peroxisome proliferator-activated receptor γ coactivator 1α (PGC-1α), a 91 kDa
transcription factor, regulates lipid metabolism and long-chain fatty acid oxidation by …

Obesity is associated with chronic inflammation, which contributes to insulin resistance and
type 2 diabetes mellitus. Under normal conditions, skeletal muscle is responsible for the …

White adipose tissue (WAT) is an endocrine organ highly integrated in homeostasis and
capable of establishing ways of communicating and influencing multiple metabolic …

Irisin is a myokine that leads to increased energy expenditure by stimulating the'browning'of
white adipose tissue. In the first description of this hormone, increased levels of circulating …