Protocadherins at the crossroad of signaling pathways
A Pancho, T Aerts, MD Mitsogiannis… - Frontiers in Molecular …, 2020 - frontiersin.org
Protocadherins (Pcdhs) are cell adhesion molecules that belong to the cadherin
superfamily, and are subdivided into clustered (cPcdhs) and non-clustered Pcdhs (ncPcdhs) …
superfamily, and are subdivided into clustered (cPcdhs) and non-clustered Pcdhs (ncPcdhs) …
How mechanisms of stem cell polarity shape the human cerebral cortex
MG Andrews, L Subramanian, J Salma… - Nature Reviews …, 2022 - nature.com
Apical–basal progenitor cell polarity establishes key features of the radial and laminar
architecture of the develo** human cortex. The unique diversity of cortical stem cell …
architecture of the develo** human cortex. The unique diversity of cortical stem cell …
Decoding cortical glial cell development
Mouse cortical radial glial cells (RGCs) are primary neural stem cells that give rise to cortical
oligodendrocytes, astrocytes, and olfactory bulb (OB) GABAergic interneurons in late …
oligodendrocytes, astrocytes, and olfactory bulb (OB) GABAergic interneurons in late …
Spatio-temporal dynamics enhance cellular diversity, neuronal function and further maturation of human cerebral organoids
P Saglam-Metiner, U Devamoglu, Y Filiz… - Communications …, 2023 - nature.com
The bioengineerined and whole matured human brain organoids stand as highly valuable
three-dimensional in vitro brain-mimetic models to recapitulate in vivo brain development …
three-dimensional in vitro brain-mimetic models to recapitulate in vivo brain development …
Transcriptional priming as a conserved mechanism of lineage diversification in the develo** mouse and human neocortex
How the rich variety of neurons in the nervous system arises from neural stem cells is not
well understood. Using single-cell RNA-sequencing and in vivo confirmation, we uncover …
well understood. Using single-cell RNA-sequencing and in vivo confirmation, we uncover …
Patterned cPCDH expression regulates the fine organization of the neocortex
X Lv, S Li, J Li, XY Yu, X Ge, B Li, S Hu, Y Lin, S Zhang… - Nature, 2022 - nature.com
The neocortex consists of a vast number of diverse neurons that form distinct layers and
intricate circuits at the single-cell resolution to support complex brain functions. Diverse cell …
intricate circuits at the single-cell resolution to support complex brain functions. Diverse cell …
[HTML][HTML] A matrigel-free method to generate matured human cerebral organoids using 3D-Printed microwell arrays
C Chen, V Rengarajan, A Kjar, Y Huang - Bioactive materials, 2021 - Elsevier
The current methods of generating human cerebral organoids rely excessively on the use of
Matrigel or other external extracellular matrices (ECM) for cell micro-environmental …
Matrigel or other external extracellular matrices (ECM) for cell micro-environmental …
Developmental origins of human cortical oligodendrocytes and astrocytes
Human cortical radial glial cells are primary neural stem cells that give rise to cortical
glutaminergic projection pyramidal neurons, glial cells (oligodendrocytes and astrocytes) …
glutaminergic projection pyramidal neurons, glial cells (oligodendrocytes and astrocytes) …
[HTML][HTML] X-chromosome regulation and sex differences in brain anatomy
A Raznahan, CM Disteche - Neuroscience & Biobehavioral Reviews, 2021 - Elsevier
Humans show reproducible sex-differences in cognition and psychopathology that may be
contributed to by influences of gonadal sex-steroids and/or sex-chromosomes on regional …
contributed to by influences of gonadal sex-steroids and/or sex-chromosomes on regional …
A genome-wide library of MADM mice for single-cell genetic mosaic analysis
Mosaic analysis with double markers (MADM) offers one approach to visualize and
concomitantly manipulate genetically defined cells in mice with single-cell resolution. MADM …
concomitantly manipulate genetically defined cells in mice with single-cell resolution. MADM …