Protocadherins at the crossroad of signaling pathways

A Pancho, T Aerts, MD Mitsogiannis… - Frontiers in Molecular …, 2020 - frontiersin.org
Protocadherins (Pcdhs) are cell adhesion molecules that belong to the cadherin
superfamily, and are subdivided into clustered (cPcdhs) and non-clustered Pcdhs (ncPcdhs) …

How mechanisms of stem cell polarity shape the human cerebral cortex

MG Andrews, L Subramanian, J Salma… - Nature Reviews …, 2022 - nature.com
Apical–basal progenitor cell polarity establishes key features of the radial and laminar
architecture of the develo** human cortex. The unique diversity of cortical stem cell …

Decoding cortical glial cell development

X Li, G Liu, L Yang, Z Li, Z Zhang, Z Xu, Y Cai, H Du… - Neuroscience …, 2021 - Springer
Mouse cortical radial glial cells (RGCs) are primary neural stem cells that give rise to cortical
oligodendrocytes, astrocytes, and olfactory bulb (OB) GABAergic interneurons in late …

Spatio-temporal dynamics enhance cellular diversity, neuronal function and further maturation of human cerebral organoids

P Saglam-Metiner, U Devamoglu, Y Filiz… - Communications …, 2023 - nature.com
The bioengineerined and whole matured human brain organoids stand as highly valuable
three-dimensional in vitro brain-mimetic models to recapitulate in vivo brain development …

Transcriptional priming as a conserved mechanism of lineage diversification in the develo** mouse and human neocortex

Z Li, WA Tyler, E Zeldich, G Santpere Baró… - Science …, 2020 - science.org
How the rich variety of neurons in the nervous system arises from neural stem cells is not
well understood. Using single-cell RNA-sequencing and in vivo confirmation, we uncover …

Patterned cPCDH expression regulates the fine organization of the neocortex

X Lv, S Li, J Li, XY Yu, X Ge, B Li, S Hu, Y Lin, S Zhang… - Nature, 2022 - nature.com
The neocortex consists of a vast number of diverse neurons that form distinct layers and
intricate circuits at the single-cell resolution to support complex brain functions. Diverse cell …

[HTML][HTML] A matrigel-free method to generate matured human cerebral organoids using 3D-Printed microwell arrays

C Chen, V Rengarajan, A Kjar, Y Huang - Bioactive materials, 2021 - Elsevier
The current methods of generating human cerebral organoids rely excessively on the use of
Matrigel or other external extracellular matrices (ECM) for cell micro-environmental …

Developmental origins of human cortical oligodendrocytes and astrocytes

L Yang, Z Li, G Liu, X Li, Z Yang - Neuroscience Bulletin, 2022 - Springer
Human cortical radial glial cells are primary neural stem cells that give rise to cortical
glutaminergic projection pyramidal neurons, glial cells (oligodendrocytes and astrocytes) …

[HTML][HTML] X-chromosome regulation and sex differences in brain anatomy

A Raznahan, CM Disteche - Neuroscience & Biobehavioral Reviews, 2021 - Elsevier
Humans show reproducible sex-differences in cognition and psychopathology that may be
contributed to by influences of gonadal sex-steroids and/or sex-chromosomes on regional …

A genome-wide library of MADM mice for single-cell genetic mosaic analysis

X Contreras, N Amberg, A Davaatseren, AH Hansen… - Cell reports, 2021 - cell.com
Mosaic analysis with double markers (MADM) offers one approach to visualize and
concomitantly manipulate genetically defined cells in mice with single-cell resolution. MADM …