Simple Summary Innate immune natural killer (NK) cells are capable of killing metastatic
cancer cells without activation by antigen-presenting cells beforehand. The cytotoxic effects …

Natural Killer (NK) cells are innate immune cells that play a pivotal role as first line
defenders in the anti-tumor response. To prevent tumor development, NK cells are …

Inflammation is a highly dynamic process with immune cells that continuously interact with
each other and parenchymal components as they migrate through tissue. The dynamic …

Despite significant advances in cancer treatment, the metastatic spread of malignant cells to
distant organs remains a major cause of cancer-related deaths. Natural killer (NK) cells play …

Natural killer (NK) cells are lymphocytes capable of controlling tumors and virus infections
through direct lysis and cytokine production. While both T and NK cells expand and …

Canonical epidermal growth factor (EGF) receptor (EGFR) activation involves the binding of
seven EGFR ligands (EGFRLs); however, their extracellular dynamics remain elusive. Here …

Metastatic renal cell carcinoma (RCC) has a poor prognosis, and the major organ of
metastasis is the lung. Immunotherapy with immune checkpoint inhibitors (ICIs) is the first …

Melanoma is among the most lethal forms of cancer, accounting for 80% of deaths despite
comprising just 5% of skin cancer cases. Treatment options remain limited due to the genetic …

In recent years, tumor immunotherapy has produced remarkable results in tumor treatment.
Nevertheless, its effects are severely limited in patients with low or absent pre-existing T cell …

Natural killer (NK) cells traffic through the blood and mount cytolytic and interferon-γ (IFNγ)-
focused responses to intracellular pathogens and tumors. Type 1 innate lymphoid cells …