Androgens play an important role in metabolic homeostasis and reproductive health in both
men and women. Androgen signalling is dependent on androgen receptor activation, mostly …

In the pathways of steroid hormone biosynthesis there are two major types of enzymes:
cytochromes P450 and other steroid oxidoreductases. This review presents an overview of …

Cytochrome P450 enzymes that metabolize estrogens are expressed in the mammary
gland, uterus, brain and other target tissues for estrogen action, and this results in the …

Evidence has been accumulating that, in men, some of the biological actions traditionally
attributed to testosterone acting via the androgen receptor may in fact be dependent on its …

THAT the testes are related to the sexual characteristics of the individual and have
reproductive power was observed at an early time in history. One of the earliest descriptions …

Defects in the conversion of androstenedione to testosterone in the fetal testes by the
enzyme 17β–hydroxysteroid dehydrogenase (17β–HSD) give rise to genetic males with …

The brain is a steroidogenic organ that expresses steroidogenic enzymes and produces
neurosteroids. Although considerable information is now available regarding the …

17β-Hydroxysteroid dehydrogenase (17β-HSD) controls the last step in the formation of all
androgens and all estrogens. This crucial role of 17β-HSD is performed by at least five 17β …

Serum androgens as well as their precursors and metabolites decrease from the age of 30–
40 yr in women, thus suggesting that a more physiological hormone replacement therapy at …

Neuroactive steroids synthesized in neuronal tissue, referred to as neurosteroids, are
implicated in proliferation, differentiation, activity and survival of nerve cells. Neurosteroids …