Amyloid fibers and oligomers are associated with a great variety of human diseases
including Alzheimer's disease and the prion conditions. Here we attempt to connect recent …

1. Introduction 3082. Plan of this article 3123. Natural mechanisms of development of novel
protein functions 3133.1 Divergence 3133.2 Recruitment 3163.3 'Mixing and matching'of …

Transmissible spongiform encephalopathies (TSEs) are inevitably lethal neurodegenerative
diseases that affect humans and a large variety of animals. The infectious agent responsible …

Recombinant mouse prion protein (recMoPrP) produced in Escherichia coli was
polymerized into amyloid fibrils that represent a subset of β sheet–rich structures. Fibrils …

A remarkable feature of prion biology is the strain phenomenon wherein prion particles
apparently composed of the same protein lead to phenotypically distinct transmissible …

Prions are infectious proteins consisting mainly of PrPSc, a β sheet–rich conformer of the
normal host protein PrPC, and occur in different strains. Strain identity is thought to be …

Genetic and environmental factors that increase the risk of late-onset Alzheimer disease are
now well recognized but the cause of variable progression rates and phenotypes of sporadic …

Building upon the success of the Handbook of Laboratory Animal Science and completing
Volumes I and II of the Second Edition, Handbook of Laboratory Animal Science, Second …

▪ Abstract The prion hypothesis proposes that proteins can act as infectious agents.
Originally formulated to explain transmissible spongiform encephalopathies (TSEs), the …

The occurrence of multiple strains of prions may reflect conformational variability of PrPSc, a
disease-associated, aggregated variant of the cellular prion protein, PrPC. Here we used …