Novel developments in the prophylaxis and treatment of acute GVHD

O Jamy, R Zeiser, YB Chen - Blood, 2023 - ashpublications.org
Acute graft-versus-host disease (aGVHD) is a major life-threatening complication after
allogeneic hematopoietic cell transplant. Traditional standard prophylaxis for aGVHD has …

How I prevent GVHD in high-risk patients: posttransplant cyclophosphamide and beyond

J Rimando, SR McCurdy, L Luznik - Blood, 2023 - ashpublications.org
Advances in conditioning, graft-versus-host disease (GVHD) prophylaxis and antimicrobial
prophylaxis have improved the safety of allogeneic hematopoietic cell transplantation (HCT) …

[HTML][HTML] American Society for Transplantation and Cellular Therapy series:# 3—prevention of cytomegalovirus infection and disease after hematopoietic cell …

M Hakki, SL Aitken, L Danziger-Isakov… - … and Cellular Therapy, 2021 - Elsevier
Abstract The Practice Guidelines Committee of the American Society for Transplantation and
Cellular Therapy partnered with its Transplant Infectious Disease Special Interest Group to …

Antiviral cellular therapy for enhancing T-cell reconstitution before or after hematopoietic stem cell transplantation (ACES): a two-arm, open label phase II …

MD Keller, PJ Hanley, YY Chi, P Aguayo-Hiraldo… - Nature …, 2024 - nature.com
Viral infections remain a major risk in immunocompromised pediatric patients, and virus-
specific T cell (VST) therapy has been successful for treatment of refractory viral infections in …

Cytomegalovirus breakthrough and resistance during letermovir prophylaxis

GA Perchetti, MA Biernacki, H **e, J Castor… - Bone Marrow …, 2023 - nature.com
Letermovir is a relatively new antiviral for prophylaxis against cytomegalovirus (CMV) after
allogeneic hematopoietic cell transplantation (HCT). CMV-seropositive HCT recipients who …

Human herpes virus-6 (HHV-6) reactivation after hematopoietic cell transplant and chimeric antigen receptor (CAR)-T cell therapy: a shifting landscape

E Kampouri, G Handley, JA Hill - Viruses, 2024 - mdpi.com
HHV-6B reactivation affects approximately half of all allogeneic hematopoietic cell transplant
(HCT) recipients. HHV-6B is the most frequent infectious cause of encephalitis following …

How I prevent viral reactivation in high-risk patients

SS Dadwal, GA Papanicolaou… - Blood, The Journal of …, 2023 - ashpublications.org
Preventing viral infections at an early stage is a key strategy for successfully improving
transplant outcomes. Preemptive therapy and prophylaxis with antiviral agents have been …

Post-transplant cyclophosphamide in one-antigen mismatched unrelated donor transplantation versus haploidentical transplantation in acute myeloid leukemia: a …

G Battipaglia, JE Galimard, M Labopin… - Bone marrow …, 2022 - nature.com
Abstract Whether to choose Haploidentical (Haplo) or one-antigen mismatched unrelated
donor (1Ag-MMUD) hematopoietic cell transplantation (HCT) with post-transplant …

Human herpesvirus 6–specific T-cell immunity in allogeneic hematopoietic stem cell transplant recipients

M Noviello, F Lorentino, E Xue, S Racca… - Blood …, 2023 - ashpublications.org
Abstract Human herpesvirus 6 (HHV-6) can reactivate after allogeneic hematopoietic stem
cell transplant (allo-HSCT) and may lead to severe symptoms. HHV-6–specific immune …

Controversies and expectations for the prevention of GVHD: a biological and clinical perspective

B Watkins, KM Williams - Frontiers in Immunology, 2022 - frontiersin.org
Severe acute and chronic graft versus host disease (GVHD) remains a major cause of
morbidity and mortality after allogeneic hematopoietic cell transplantation. Historically, cord …