Machine learning-guided protein engineering
Recent progress in engineering highly promising biocatalysts has increasingly involved
machine learning methods. These methods leverage existing experimental and simulation …
machine learning methods. These methods leverage existing experimental and simulation …
Epithelial sodium channel (ENaC) family: Phylogeny, structure–function, tissue distribution, and associated inherited diseases
The epithelial sodium channel (ENaC) is composed of three homologous subunits and
allows the flow of Na+ ions across high resistance epithelia, maintaining body salt and water …
allows the flow of Na+ ions across high resistance epithelia, maintaining body salt and water …
BRENDA, the ELIXIR core data resource in 2021: new developments and updates
The BRENDA enzyme database (https://www. brenda-enzymes. org), established in 1987,
has evolved into the main collection of functional enzyme and metabolism data. In 2018 …
has evolved into the main collection of functional enzyme and metabolism data. In 2018 …
The IUPHAR/BPS Guide to PHARMACOLOGY in 2018: updates and expansion to encompass the new guide to IMMUNOPHARMACOLOGY
Abstract The IUPHAR/BPS Guide to PHARMACOLOGY (GtoPdb, www.
guidetopharmacology. org) and its precursor IUPHAR-DB, have captured expert-curated …
guidetopharmacology. org) and its precursor IUPHAR-DB, have captured expert-curated …
The SWISS-MODEL Repository—new features and functionality
S Bienert, A Waterhouse, TAP De Beer… - Nucleic acids …, 2017 - academic.oup.com
Abstract SWISS-MODEL Repository (SMR) is a database of annotated 3D protein structure
models generated by the automated SWISS-MODEL homology modeling pipeline. It …
models generated by the automated SWISS-MODEL homology modeling pipeline. It …
InterPro in 2017—beyond protein family and domain annotations
Abstract InterPro (http://www. ebi. ac. uk/interpro/) is a freely available database used to
classify protein sequences into families and to predict the presence of important domains …
classify protein sequences into families and to predict the presence of important domains …
PDBsum: Structural summaries of PDB entries
PDBsum is a web server providing structural information on the entries in the Protein Data
Bank (PDB). The analyses are primarily image‐based and include protein secondary …
Bank (PDB). The analyses are primarily image‐based and include protein secondary …
BeStSel: a web server for accurate protein secondary structure prediction and fold recognition from the circular dichroism spectra
Circular dichroism (CD) spectroscopy is a widely used method to study the protein
secondary structure. However, for decades, the general opinion was that the correct …
secondary structure. However, for decades, the general opinion was that the correct …
Protein structure generation via folding diffusion
The ability to computationally generate novel yet physically foldable protein structures could
lead to new biological discoveries and new treatments targeting yet incurable diseases …
lead to new biological discoveries and new treatments targeting yet incurable diseases …
HMMER web server: 2015 update
The HMMER website, available at http://www. ebi. ac. uk/Tools/hmmer/, provides access to
the protein homology search algorithms found in the HMMER software suite. Since the first …
the protein homology search algorithms found in the HMMER software suite. Since the first …