Calcium signalling in T cells
M Trebak, JP Kinet - Nature Reviews Immunology, 2019 - nature.com
Abstract Calcium (Ca2+) signalling is of paramount importance to immunity. Regulated
increases in cytosolic and organellar Ca2+ concentrations in lymphocytes control complex …
increases in cytosolic and organellar Ca2+ concentrations in lymphocytes control complex …
Lysosomal biology and function: modern view of cellular debris bin
PC Trivedi, JJ Bartlett, T Pulinilkunnil - Cells, 2020 - mdpi.com
Lysosomes are the main proteolytic compartments of mammalian cells comprising of a
battery of hydrolases. Lysosomes dispose and recycle extracellular or intracellular …
battery of hydrolases. Lysosomes dispose and recycle extracellular or intracellular …
The roles of calcium and ATP in the physiology and pathology of the exocrine pancreas
This review deals with the roles of calcium ions and ATP in the control of the normal
functions of the different cell types in the exocrine pancreas as well as the roles of these …
functions of the different cell types in the exocrine pancreas as well as the roles of these …
Agonist-mediated switching of ion selectivity in TPC2 differentially promotes lysosomal function
Ion selectivity is a defining feature of a given ion channel and is considered immutable. Here
we show that ion selectivity of the lysosomal ion channel TPC2, which is hotly debated …
we show that ion selectivity of the lysosomal ion channel TPC2, which is hotly debated …
TPC proteins are phosphoinositide-activated sodium-selective ion channels in endosomes and lysosomes
Mammalian two-pore channel proteins (TPC1, TPC2; TPCN1, TPCN2) encode ion channels
in intracellular endosomes and lysosomes and were proposed to mediate endolysosomal …
in intracellular endosomes and lysosomes and were proposed to mediate endolysosomal …
Essential requirement for JPT2 in NAADP-evoked Ca2+ signaling
Nicotinic acid adenine dinucleotide phosphate (NAADP) is a second messenger that
releases Ca2+ from acidic organelles through the activation of two-pore channels (TPCs) to …
releases Ca2+ from acidic organelles through the activation of two-pore channels (TPCs) to …
Intracellular Ca2+ signaling and Ca2+ microdomains in the control of cell survival, apoptosis and autophagy
The endoplasmic reticulum (ER), mitochondria and lysosomes are physically and/or
functionally linked, establishing close contact sites between these organelles. As a …
functionally linked, establishing close contact sites between these organelles. As a …
The role of transient receptor potential cation channels in Ca2+ signaling
M Gees, B Colsoul, B Nilius - Cold Spring Harbor …, 2010 - cshperspectives.cshlp.org
The 28 mammalian members of the super-family of transient receptor potential (TRP)
channels are cation channels, mostly permeable to both monovalent and divalent cations …
channels are cation channels, mostly permeable to both monovalent and divalent cations …
Molecular mechanisms of endolysosomal Ca2+ signalling in health and disease
AJ Morgan, FM Platt, E Lloyd-Evans… - Biochemical …, 2011 - portlandpress.com
Endosomes, lysosomes and lysosome-related organelles are emerging as important Ca2+
storage cellular compartments with a central role in intracellular Ca2+ signalling …
storage cellular compartments with a central role in intracellular Ca2+ signalling …
Structure of the voltage-gated two-pore channel TPC1 from Arabidopsis thaliana
Two-pore channels (TPCs) contain two copies of a Shaker-like six-transmembrane (6-TM)
domain in each subunit and are ubiquitously expressed in both animals and plants as …
domain in each subunit and are ubiquitously expressed in both animals and plants as …