Thrombosis with associated inflammation (thromboinflammation) occurs commonly in a
broad range of human disorders. It is well recognized clinically in the context of superficial …

Therapeutic anticoagulation is indicated for a variety of circumstances and conditions in
several fields of medicine to prevent or treat venous and arterial thromboembolism …

Summary Background Asundexian (Bayer AG, Leverkusen, Germany), an oral small
molecule factor XIa (FXIa) inhibitor, might prevent thrombosis without increasing bleeding …

Background People with factor XI deficiency have lower rates of ischaemic stroke than the
general population and infrequent spontaneous bleeding, suggesting that factor XI has a …

The plasma coagulation system in mammalian blood consists of a cascade of enzyme
activation events in which serine proteases activate the proteins (proenzymes and …

Activation of the intrinsic pathway of coagulation contributes to the pathogenesis of arterial
and venous thrombosis. Critical insights into the involvement of intrinsic pathway factors …

The formation of blood clots—thrombosis—at sites of atherosclerotic plaque rupture is a
major clinical problem despite ongoing improvements in antithrombotic therapy. Progress in …

Mechanisms of Thrombus Formation | New England Journal of Medicine Skip to main content
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1166 Stroke April 2016 ischemic stroke progression. 5 Stroke injury was significantly
reduced on blocking the interaction between platelet GP VI and collagen. 6 Similarly, when …

Platelets play a central role in thrombosis, hemostasis, and inflammation. We show that
activated platelets release inorganic polyphosphate (polyP), a polymer of 60–100 …