Mammalian basic HLH (helix–loop–helix)–PER–ARNT–SIM (bHLH–PAS) proteins are
heterodimeric transcription factors that sense and respond to environmental signals (such as …

Prostate cancer (PC), which has high morbidity and mortality among elderly men, is
becoming the most common malignancy in men. The progression of PC is associated with …

Cancer-associated genetic alterations induce expression of tumour antigens that can
activate CD8+ cytotoxic T cells (CTLs), but the microenvironment of established tumours …

The androgen receptor (AR) plays a central role in establishing an oncogenic cascade that
drives prostate cancer progression. Some prostate cancers escape androgen dependence …

Prostate cancers remain indolent in the majority of individuals but behave aggressively in a
minority,. The molecular basis for this clinical heterogeneity remains incompletely …

Prostate cancer (PCa) is a common and fatal type of cancer in men. Metastatic PCa (mPCa)
is a major factor contributing to its lethality, although the mechanisms remain poorly …

Purpose: The major obstacle in the management of advanced prostate cancer is the
occurrence of resistance to endocrine therapy. Although the androgen receptor (AR) has …

Genome-wide association studies (GWAS) have identified rs11672691 at 19q13 associated
with aggressive prostate cancer (PCa). Here, we independently confirmed the finding in a …

Prostate cancer is the most commonly diagnosed malignancy among men in industrialized
countries, accounting for the second leading cause of cancer-related deaths. Although we …

Resistance to androgen deprivation therapies and increased androgen receptor (AR)
activity are major drivers of castration-resistant prostate cancer (CRPC). Although prior work …