Motile and non-motile (primary) cilia are nearly ubiquitous cellular organelles. The
dysfunction of cilia causes diseases known as ciliopathies. The number of reported …

Mucociliary clearance (MCC) is the primary innate defense mechanism of the lung. The
functional components are the protective mucous layer, the airway surface liquid layer, and …

The cilium is a complex organelle, the assembly of which requires the coordination of motor-
driven intraflagellar transport (IFT), membrane trafficking and selective import of cilium …

Chlamydomonas reinhardtii is a unicellular green alga whose lineage diverged from land
plants over 1 billion years ago. It is a model system for studying chloroplast-based …

Primary cilium dysfunction underlies the pathogenesis of Bardet-Biedl syndrome (BBS), a
genetic disorder whose symptoms include obesity, retinal degeneration, and nephropathy …

Defects in the function of cellular organelles such as peroxisomes, lysosomes and
mitochondria are well-known causes of human diseases. Recently, another organelle has …

Ionotropic glutamate receptors (iGluRs) are ligand-gated ion channels that mediate
chemical communication between neurons at synapses. A variant iGluR subfamily, the …

Intraflagellar transport (IFT) trains are massive molecular machines that traffic proteins
between cilia and the cell body. Each IFT train is a dynamic polymer of two large complexes …

Cilia and flagella are ancient, evolutionarily conserved organelles that project from cell
surfaces to perform diverse biological roles, including whole-cell locomotion; movement of …

Drosophila olfactory sensory neurons (OSNs) each express two odorant receptors (ORs): a
divergent member of the OR family and the highly conserved, broadly expressed receptor …