The pathogenesis of idiopathic pulmonary fibrosis (IPF) involves a complex interplay of cell
types and signaling pathways. Recurrent alveolar epithelial cell (AEC) injury may occur in …

Idiopathic pulmonary fibrosis (IPF) is a progressive, lethal fibrotic lung disease that occurs
primarily in middle-aged and elderly adults. It is a major cause of morbidity and mortality …

Idiopathic pulmonary fibrosis (IPF) is a chronic progressive disease of unknown cause
characterized by relentless scarring of the lung parenchyma leading to reduced quality of life …

The airway epithelium serves as the interface between the host and external environment. In
many chronic lung diseases, the airway is the site of substantial remodeling after injury …

Background The remarkable growth of genome-wide association studies (GWAS) has
created a critical need to experimentally validate the disease-associated variants, 90% of …

Rationale: The incidence and sites of mucus accumulation and molecular regulation of
mucin gene expression in coronavirus (COVID-19) lung disease have not been reported …

Cystic fibrosis (CF) lung disease is characterized by early and persistent mucus
accumulation and neutrophilic inflammation in the distal airways. Identification of the factors …

Idiopathic pulmonary fibrosis (IPF) is a fatal disease with incompletely understood aetiology
and limited treatment options. Traditionally, IPF was believed to be mainly caused by …

Epithelial cell dysfunction has emerged as a central component of the pathophysiology of
diffuse parenchymal diseases including idiopathic pulmonary fibrosis (IPF). Alveolar type 2 …

Question Cystic fibrosis (CF) is characterised by the accumulation of viscous adherent
mucus in the lungs. While several hypotheses invoke a direct relationship with cystic fibrosis …