Prognostic biomarkers of cell proliferation in colorectal cancer (CRC): from immunohistochemistry to molecular biology techniques
A Kasprzak - Cancers, 2023 - mdpi.com
Simple Summary This review aims to shed light on the proliferative markers important in the
everyday clinical management of colorectal cancer (CRC), ranging from simple methods of …
everyday clinical management of colorectal cancer (CRC), ranging from simple methods of …
From APC to the genetics of hereditary and familial colon cancer syndromes
AP Olkinuora, PT Peltomäki, LA Aaltonen… - Human Molecular …, 2021 - academic.oup.com
Hereditary colorectal cancer (CRC) syndromes attributable to high penetrance mutations
represent 9–26% of young-onset CRC cases. The clinical significance of many of these …
represent 9–26% of young-onset CRC cases. The clinical significance of many of these …
[HTML][HTML] Association of Genetic Variants at the CDKN1B and CCND2 Loci Encoding p27Kip1 and Cyclin D2 Cell Cycle Regulators with Susceptibility and Clinical …
L Ciszak, A Kosmaczewska, E Pawlak… - International Journal of …, 2024 - mdpi.com
Beyond the essential role of p27 Kip1 and cyclin D2 in cell cycle progression, they are also
shown to confer an anti-apoptotic function in peripheral blood (PB) lymphocytes. Although …
shown to confer an anti-apoptotic function in peripheral blood (PB) lymphocytes. Although …
Germline and somatic whole-exome sequencing identifies new candidate genes involved in familial predisposition to serrated polyposis syndrome
Simple Summary Cancer is the second leading cause of death worldwide. Serrated
polyposis syndrome (SPS) is characterized by the presence of serrated lesions in the colon …
polyposis syndrome (SPS) is characterized by the presence of serrated lesions in the colon …
Unraveling the impact of a germline heterozygous POLD1 frameshift variant in serrated polyposis syndrome
Serrated polyposis syndrome (SPS) is one of the most frequent polyposis syndromes
characterized by an increased risk for develo** colorectal cancer (CRC). Although SPS …
characterized by an increased risk for develo** colorectal cancer (CRC). Although SPS …
[HTML][HTML] TMBIM1 promotes proliferation and attenuates apoptosis in glioblastoma cells by targeting the p38 MAPK signalling pathway
J Cai, L Gao, Y Wang, Y Li, Z Ye, S Tong, T Yan… - Translational …, 2022 - Elsevier
Glioblastoma multiforme (GBM) is the most common and most fatal primary malignant brain
tumour in adults. The average survival time of patients after diagnosis is only 12–15 months …
tumour in adults. The average survival time of patients after diagnosis is only 12–15 months …
Non-lynch familial and early-onset colorectal cancer explained by accumulation of low-risk genetic variants
Simple Summary A relevant proportion of colorectal cancer patients diagnosed at young age
and/or with family history of that type of cancer do not carry germline mutations in know …
and/or with family history of that type of cancer do not carry germline mutations in know …
Genome-wide association study of colorectal polyps identified highly overlap** polygenic architecture with colorectal cancer
No genome-wide association studies (GWAS) were reported for colorectal polyps and the
overlap in polygenic backgrounds conferring risk of colorectal cancer and polyps remains …
overlap in polygenic backgrounds conferring risk of colorectal cancer and polyps remains …
Prostate Cancer Susceptibility Loci Identified in GATA2 and ZMIZ1 in Chinese Population
HJ Zhang, Z Liu, L Kan - International Journal of Genomics, 2022 - Wiley Online Library
Background. Common genetic risk variants for prostate cancer (PCa) have been identified at
approximately 170 loci using genome‐wide association studies (GWAS), most of which were …
approximately 170 loci using genome‐wide association studies (GWAS), most of which were …
ZMIZ1 Regulates Proliferation, Autophagy and Apoptosis of Colon Cancer Cells by Mediating Ubiquitin–Proteasome Degradation of SIRT1
M Huang, J Wang, Z Zhang, X Zuo - Biochemical Genetics, 2024 - Springer
There are nearly 1.15 million new cases of colon cancer, as well as 586,858 deaths from
colon cancer worldwide in 2020. The aim of this study is to reveal whether ZMIZ1 can control …
colon cancer worldwide in 2020. The aim of this study is to reveal whether ZMIZ1 can control …