From intestinal colonization to systemic infections: Candida albicans translocation and dissemination

JL Sprague, L Kasper, B Hube - Gut Microbes, 2022 - Taylor & Francis
Candida species are the most prevalent cause of invasive fungal infections, of which
Candida albicans is the most common. Translocation across the epithelial barrier into the …

Candida albicans dwelling in the mammalian gut

JC Pérez - Current opinion in microbiology, 2019 - Elsevier
The yeast Candida albicans inhabits the gastrointestinal tract of most healthy adults,
seemingly living there as a harmless commensal. The fungus on occasion disseminates …

Glucose depletion enables Candida albicans mating independently of the epigenetic white-opaque switch

G Guan, L Tao, C Li, M Xu, L Liu, RJ Bennett… - Nature …, 2023 - nature.com
The human fungal pathogen Candida albicans can switch stochastically and heritably
between a “white” phase and an “opaque” phase. Opaque cells are the mating-competent …

Pulsed Electric Field-Assisted Sensitization of Multidrug-Resistant Candida Albicans to Antifungal Drugs

V Novickij, J Švedienė, A Paškevičius… - Future …, 2018 - Taylor & Francis
Aim: Determine the influence of pH on the inactivation efficiency of Candida albicans in
pulsed electric fields (PEF) and evaluate the possibilities for sensitization of a drug-resistant …

Small molecule inhibitors of fungal Δ(9) fatty acid desaturase as antifungal agents against Candida auris

F Tebbji, ACT Menon, I Khemiri, DJ St-Cyr… - Frontiers in Cellular …, 2024 - frontiersin.org
Candida auris has emerged as a significant healthcare-associated pathogen due to its
multidrug-resistant nature. Ongoing constraints in the discovery and provision of new …

Mms21: A Putative SUMO E3 Ligase in Candida albicans That Negatively Regulates Invasiveness and Filamentation, and Is Required for the Genotoxic and Cellular …

A Islam, F Tebbji, J Mallick, H Regan, V Dumeaux… - Genetics, 2019 - academic.oup.com
In the life cycle of the fungal pathogen Candida albicans, the formation of filamentous cells is
a differentiation process that is critically involved in host tissue invasion, and in adaptation to …

[HTML][HTML] The LAMMER Kinase MoKns1 Regulates Growth, Conidiation and Pathogenicity in Magnaporthe oryzae

L Li, XM Zhu, JQ Wu, N Cao, JD Bao, XH Liu… - International Journal of …, 2022 - mdpi.com
Magnaporthe oryzae is an important pathogen that causes a devastating disease in rice. It
has been reported that the dual-specificity LAMMER kinase is conserved from yeast to …

Flip/flop mating-type switching in the methylotrophic yeast Ogataea polymorpha is regulated by an Efg1-Rme1-Ste12 pathway

SJ Hanson, KP Byrne, KH Wolfe - PLoS genetics, 2017 - journals.plos.org
In haploid cells of Ogataea (Hansenula) polymorpha an environmental signal, nitrogen
starvation, induces a reversible change in the structure of a chromosome. This process …

Screening of Candida albicans GRACE library revealed a unique pattern of biofilm formation under repression of the essential gene ILS1

ACBP Costa, RP Omran, TO Correia-Mesquita… - Scientific Reports, 2019 - nature.com
Candida albicans biofilm formation is governed by a regulatory circuit comprising nine
transcription factors which control a network of target genes. However, there are still …

[HTML][HTML] Loss of Arp1, a putative actin-related protein, triggers filamentous and invasive growth and impairs pathogenicity in Candida albicans

S Yao, Y Feng, A Islam, M Shrivastava, H Gu… - Computational and …, 2020 - Elsevier
The polymorphous cellular shape of Candida albicans, in particular the transition from a
yeast to a filamentous form, is crucial for either commensalism or life-threatening infections …