Skin barrier dysfunction, a defining feature of atopic dermatitis (AD), arises from multiple
interacting systems. In AD, skin inflammation is caused by host–environment interactions …

The discovery in 2006 that loss-of-function mutations in the filaggrin gene (FLG) cause
ichthyosis vulgaris and can predispose to atopic dermatitis (AD) galvanized the dermatology …

Objective To provide an overview of filaggrin biology and the role of filaggrin variants in
atopic dermatitis (AD) and allergic disease. Data Sources We performed a PubMed literature …

Background Atopic dermatitis is the most common chronic inflammatory skin disorder,
affecting up to 20% of children and 10% of adults in industrialized countries. This highly …

Human skin acts as a primary barrier between the body and its environment. Crucial for this
skin barrier function is the lipid matrix in the outermost layer of the skin, the stratum corneum …

Atopic dermatitis (AD) is the most common chronic inflammatory skin disease. It often
precedes the development of food allergy and asthma. Recent insights into AD reveal …

Allergic diseases have in common a dysfunctional epithelial barrier, which allows the
penetration of allergens and microbes, leading to the release of type 2 cytokines that drive …

Background Atopic dermatitis (AD) is a chronic inflammatory disease caused by the complex
interaction of genetic, immune and environmental factors. There have many recent …

The epidermis protects human subjects from exogenous stressors and helps to maintain
internal fluid and electrolyte homeostasis. Filaggrin is a crucial epidermal protein that is …

The discovery, in 2006, that loss-of-function mutations in the filaggrin (FLG) gene are the
cause of ichthyosis vulgaris—the most common disorder of keratinization—and also a strong …