Non-exosomal and exosomal circulatory microRNAs: which are more valid as biomarkers?

NNSB Nik Mohamed Kamal… - Frontiers in …, 2020 - frontiersin.org
MicroRNAs (miRNAs) are a group of small non-coding RNAs with approximately 19–25
nucleotides that are involved in regulating a range of developmental and physiological …

Methodologies to isolate and purify clinical grade extracellular vesicles for medical applications

A Akbar, F Malekian, N Baghban, SP Kodam, M Ullah - Cells, 2022 - mdpi.com
The use of extracellular vesicles (EV) in nano drug delivery has been demonstrated in many
previous studies. In this study, we discuss the sources of extracellular vesicles, including …

[HTML][HTML] M2 microglia-derived exosomes protect the mouse brain from ischemia-reperfusion injury via exosomal miR-124

Y Song, Z Li, T He, M Qu, L Jiang, W Li, X Shi, J Pan… - Theranostics, 2019 - ncbi.nlm.nih.gov
Rationale: Microglia play a critical role in modulating cell death and neurobehavioral
recovery in response to brain injury either by direct cell-cell interaction or indirect secretion …

[HTML][HTML] Exosomal miRNAs in central nervous system diseases: biomarkers, pathological mediators, protective factors and therapeutic agents

X **a, Y Wang, Y Huang, H Zhang, H Lu… - Progress in …, 2019 - Elsevier
Exosomes are small bilipid layer-enclosed extracellular vesicles that can be found in tissues
and biological fluids. As a key cell-to-cell and distant communication mediator, exosomes …

Exosomes derived from microRNA-138-5p-overexpressing bone marrow-derived mesenchymal stem cells confer neuroprotection to astrocytes following ischemic …

Y Deng, D Chen, F Gao, H Lv, G Zhang, X Sun… - Journal of biological …, 2019 - Springer
Background MicroRNAs (miRNAs) are implicated in the progression of ischemic stroke (IS)
and bone marrow-derived mesenchymal stem cells (BMSCs)-derived exosomes play a role …

Exosomal KLF3-AS1 from hMSCs promoted cartilage repair and chondrocyte proliferation in osteoarthritis

Y Liu, R Zou, Z Wang, C Wen, F Zhang… - Biochemical …, 2018 - portlandpress.com
The present study was designed to explore whether exosomal lncRNA-KLF3-AS1 derived
from human mesenchymal stem cells (hMSCs) can serve as a positive treatment for …

The therapeutic and diagnostic role of exosomes in cardiovascular diseases

P Zamani, N Fereydouni, AE Butler… - Trends in cardiovascular …, 2019 - Elsevier
Exosomes are nano-sized membranous vesicles that are secreted by cells. They have an
important role in transferring proteins, mRNA, miRNA and other bioactive molecules …

MicroRNAs as diagnostic and prognostic biomarkers in ischemic stroke—a comprehensive review and bioinformatic analysis

C Eyileten, Z Wicik, S De Rosa, D Mirowska-Guzel… - Cells, 2018 - mdpi.com
Stroke is the second-most common cause of death worldwide. The pathophysiology of
ischemic stroke (IS) is related to inflammation, atherosclerosis, blood coagulation, and …

A systematic review of the research progress of non-coding RNA in neuroinflammation and immune regulation in cerebral infarction/ischemia-reperfusion injury

K Yang, L Zeng, A Ge, S Wang, J Zeng, X Yuan… - Frontiers in …, 2022 - frontiersin.org
Cerebral infarction/ischemia-reperfusion injury is currently the disease with the highest
mortality and disability rate of cardiovascular disease. Current studies have shown that …

Brain‐derived extracellular vesicles: Potential diagnostic biomarkers for central nervous system diseases

X Xu, Z Iqbal, L Xu, C Wen, L Duan… - Psychiatry and …, 2024 - Wiley Online Library
Extracellular vesicles (EVs) are membrane‐enclosed nanovesicles secreted by cells into the
extracellular space and contain functional biomolecules, eg signaling receptors, bioactive …