Nanocarrier based approaches for targeting breast cancer stem cells

SKSS Pindiprolu, PT Krishnamurthy… - Artificial cells …, 2018 - Taylor & Francis
Breast cancer stem cells (BCSCs) are heterogeneous subpopulation of tumour initiating
cells within breast tumours. They are spared even after chemotherapy and responsible for …

Formulation-optimization of solid lipid nanocarrier system of STAT3 inhibitor to improve its activity in triple negative breast cancer cells

SKSS Pindiprolu, PK Chintamaneni… - Drug development …, 2019 - Taylor & Francis
In the present study, solid lipid nanoparticles (SLNs) have been formulated as a carrier
system for effective intracellular delivery of STAT3 inhibitor, niclosamide (Niclo) to triple …

RAGE receptor targeted bioconjuguate lipid nanoparticles of diallyl disulfide for improved apoptotic activity in triple negative breast cancer: in vitro studies

VT Siddhartha, SKSS Pindiprolu… - Artificial cells …, 2018 - Taylor & Francis
In the present study, we have demonstrated receptor for advanced glycation endproducts
(RAGE) as a target for delivery of drugs specifically to triple negative breast cancer cells. We …

DR5 antibody conjugated lipid-based nanocarriers of gamma-secretase inhibitor for the treatment of triple negative breast cancer

SKSS Pindiprolu, PT Krishnamurthy, C Dev… - Chemistry and Physics …, 2021 - Elsevier
In the present study, Death receptor-5 (DR5) antibody conjugated solid lipid nanoparticles
(DR5-DAPT-SLNs) has been formulated for effective intracellular of γ-secretase inhibitor, N …