Decades of research have mapped out the basic mechanics of the Hippo pathway. The
paralogues Yes-associated protein (YAP) and transcriptional co-activator with PDZ-binding …

Tumorigenesis is a highly complex process, involving many interrelated and cross-acting
signalling pathways. One such pathway that has garnered much attention in the field of …

Cell-free DNA (cfDNA) has attracted significant attention due to its high potential to diagnose
diseases, such as cancer. Still, its detection by amplification method has limitations because …

The proteome provides unique insights into disease biology beyond the genome and
transcriptome. A lack of large proteomic datasets has restricted the identification of new …

Combination of anti-cancer drugs is broadly seen as way to overcome the often-limited
efficacy of single agents. The design and testing of combinations are however very …

CRISPR-Cas9 viability screens are increasingly performed at a genome-wide scale across
large panels of cell lines to identify new therapeutic targets for precision cancer therapy …

Distilling biologically meaningful information from cancer genome sequencing data requires
comprehensive identification of somatic alterations using rigorous computational methods …

Head and neck squamous cell carcinomas (HNSCCs) are amongst the most aggressive,
complex, and heterogeneous malignancies. The standard of care treatments for HNC …

YAP1 is a transcriptional co-activator whose activity is controlled by the Hippo signaling
pathway. In addition to important functions in normal tissue homeostasis and regeneration …

Microsatellite-unstable (MSI) cancers require WRN helicase to resolve replication stress due
to expanded DNA (TA) n dinucleotide repeats. WRN is a promising synthetic lethal target for …