The cingulum bundle is a prominent white matter tract that interconnects frontal, parietal, and
medial temporal sites, while also linking subcortical nuclei to the cingulate gyrus. Despite its …

For more than one century, brain processing was mainly thought in a localizationist
framework, in which one given function was underpinned by a discrete, isolated cortical …

Standard models of episodic memory focus on hippocampal–parahippocampal interactions,
with the neocortex supplying sensory information and providing a final repository of …

The uncinate fasciculus is a bidirectional, long-range white matter tract that connects lateral
orbitofrontal cortex and Brodmann area 10 with the anterior temporal lobes. Although …

Cognition arises as a result of coordinated processing among distributed brain regions and
disruptions to communication within these neural networks can result in cognitive …

The brain is a dynamic structure with the extracellular space (ECS) taking up almost a
quarter of its volume,. Signalling molecules, neurotransmitters and nutrients transit via the …

Cerebellar involvement in cognition, as well as in sensorimotor control, is increasingly
recognized and is thought to depend on connections with the cerebral cortex. Anatomical …

Objective To assess the safety, tolerability, and pharmacokinetic and pharmacodynamic
effects of the γ-secretase inhibitor avagacestat in patients with mild to moderate Alzheimer …

The uncinate fasciculus (UF) is a long-range white matter tract that connects limbic regions
in the temporal lobe to the frontal lobe. The UF is one of the latest develo** tracts, and …

Diffusion MRI has been successful in identifying the existence of white matter abnormalities
in schizophrenia in vivo. However, the role of these abnormalities in the etiology of …